ICA1L and DPY30

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ICA1L	DPY30
Description		islet cell autoantigen 1 like	dpy-30 histone methyltransferase complex regulatory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Endomembrane System Secretory Granule Membrane	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding Membrane Curvature Sensor Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Spermatid Development Regulation Of Secretion Membrane Bending	Chromatin Organization Endosomal Transport Transcription Initiation-coupled Chromatin Remodeling
Pathways			PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density ( 28869591) Lacunar stroke ( 33773637) Mean platelet volume ( 32888494) Microalbuminuria ( 31511532) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Platelet count ( 32888494) Spontaneous coronary artery dissection ( 32887874) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) White matter hyperintensities ( 32358547) White matter integrity (fractional anisotropy) ( 32358547)	Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		9 interacting genes: DPY30 GCC1 HGS KIFC3 KRT27 LMO2 MTDH RCOR3 TNPO3	33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19
Entrez ID		130026	84661
HPRD ID		12447	17434
Ensembl ID		ENSG00000163596	ENSG00000162961
Uniprot IDs		Q8NDH6 Q96Q33	Q9C005
PDB IDs			3G36 4RIQ 4RT4 4RTA 6E2H 6PWV 7UD5
Enriched GO Terms of Interacting Partners?			Set1C/COMPASS Complex Gonadal Mesoderm Development Histone Methyltransferase Complex Chromatin Remodeling Nucleosome Assembly Nucleosome Organization Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Chromatin Organization Mesoderm Development Mesenchyme Development MLL3/4 Complex Histone H3K4 Methyltransferase Activity Proteasome Accessory Complex Protein-DNA Complex Assembly Midbody Abscission Beta-catenin Binding Protein Kinase A Regulatory Subunit Binding Mitotic Cytokinetic Process 9+2 Motile Cilium Axoneme
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