PPP1R21 and RTN4

		PPP1R21	RTN4
Description		protein phosphatase 1 regulatory subunit 21	reticulon 4
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GO Annotations	Cellular Component	Endosome Early Endosome Membrane Early Endosome Membrane	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Membrane Cell Junction Cell Projection Neuron Projection Neuronal Cell Body Synapse Anchoring Junction Endoplasmic Reticulum Tubular Network Postsynapse Endoplasmic Reticulum Tubular Network Membrane Glutamatergic Synapse
	Molecular Function	RNA Binding MRNA Binding Protein Binding Protein-macromolecule Adaptor Activity	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding
	Biological Process	Regulation Of Intracellular MRNA Localization	Blastocyst Formation Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Endoplasmic Reticulum Organization Nervous System Development Axonal Fasciculation Brain Development Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia-guided Migration Central Nervous System Vasculogenesis Neuron Differentiation Negative Regulation Of Cell Growth Regulation Of Cell Migration Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Rac Protein Signal Transduction Cell Migration Involved In Vasculogenesis Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Modulation Of Chemical Synaptic Transmission Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Nervous System Development Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Cytokine Production Protein Localization To Lysosome Cellular Response To Hypoxia Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Intracellular Sphingolipid Homeostasis Cell Adhesion Involved In Sprouting Angiogenesis Regulation Of Postsynapse Assembly Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Neutrophil Migration Positive Regulation Of Macrophage Migration Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Positive Regulation Of Artery Morphogenesis Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Vasculogenesis
Pathways			Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Chronotype ( 30696823) Colorectal cancer ( 30529582) Educational attainment ( 27046643) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Joint mobility (Beighton score) ( 27182965) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin concentration ( 29403010) Prudent dietary pattern ( 28644415) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301)	Adult body size ( 32376654) Fasting glucose ( 34074324) Lymphocyte count ( 32888494) Obesity (extreme) ( 19553259) Platelet count ( 32888494) Systolic blood pressure ( 30224653 32902719)
Interacting Genes		6 interacting genes: CFTR FBXO7 MTNR1B SH2D2A SH3GL2 ZDHHC17	49 interacting genes: BAIAP2 BCL2 BCL2L1 BDKRB1 CCR4 CERT1 CHRM4 CLN8 CNTNAP1 CRMP1 CYSLTR2 DRD2 ERBB2 ERBB3 ERBB4 F2RL1 FXR2 GLP1R GPR35 HLA-DPB1 HTR2C LAMA4 LINC01554 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 OGT PLEKHF2 POT1 PRR13 RAB33A RNF10 RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21
Entrez ID		129285	57142
HPRD ID		17294	07259
Ensembl ID		ENSG00000162869	ENSG00000115310
Uniprot IDs		Q6ZMI0	Q9NQC3
PDB IDs		7ND2	2G31 2JV5
Enriched GO Terms of Interacting Partners?		Golgi-associated Vesicle Membrane Regulation Of Cell Communication Clathrin-coated Endocytic Vesicle Membrane Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Developmental Process Regulation Of Intracellular Signal Transduction Synapse Regulation Of ERBB Signaling Pathway Perforant Pathway To Dendrate Granule Cell Synapse Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Positive Regulation Of Anion Channel Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Blood-brain Barrier Permeability Glutamatergic Synapse Lewy Body Core Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Biological Quality Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Programmed Cell Death Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Signal Transduction Regulation Of Neuronal Action Potential Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Neuron Apoptotic Process Photoreceptor Ribbon Synapse	Neuregulin Receptor Activity Membrane Organization Signal Transduction G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Presynapse ERBB3:ERBB2 Complex Glutamatergic Synapse Cell Projection Morphogenesis Dendritic Cell Apoptotic Process Membrane Neuromuscular Process Neuron Differentiation Response To Epidermal Growth Factor Protein Localization To Synapse Regulation Of Synapse Organization ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Rho Protein Signal Transduction ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway BH3 Domain Binding Cell Surface Receptor Signaling Pathway Cell Junction Organization Myelin Sheath Axonogenesis ERBB Signaling Pathway Endosome Neuromuscular Junction Non-canonical Inflammasome Complex Assembly Shelterin Complex Neuronal Signal Transduction Protein Localization To Cell Junction Mitochondrion Organization Cell Junction Assembly Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Projection Morphogenesis Signaling Receptor Activity Myelination Axon Ensheathment Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Establishment Of Localization In Cell Regulation Of ERK1 And ERK2 Cascade GABA-ergic Synapse Positive Regulation Of ERK1 And ERK2 Cascade Ceramide Binding ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway
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