TCP11L1 and ERCC6L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCP11L1	ERCC6L2
Description		t-complex 11 like 1	ERCC excision repair 6 like 2
Image		No pdb structure
GO Annotations	Cellular Component	Microtubule	Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Mitochondrion Centrosome Cytoskeleton Protein-containing Complex
	Molecular Function	Protein Binding	Nucleotide Binding DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	Signal Transduction	DNA Repair DNA Damage Response Cellular Response To Reactive Oxygen Species Interstrand Cross-link Repair Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways
Drugs
Diseases
GWAS		Anger ( 24489884) Platelet distribution width ( 32888494)	Adult body size ( 32376654) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Hip circumference adjusted for BMI ( 34021172) Monobrow ( 27182965) Parkinson's disease (pesticide exposure interaction) ( 27545685) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		24 interacting genes: APP CNOT7 DDIT4L ERCC6L2 HMG20A IKBKG IPO4 LHX2 MAGEA12 MEOX1 NEDD4 OGT PAX6 PLEKHS1 PRXL2B PSMD4 REL SDCBP2 SNW1 TBX6 TRIM21 TSNAX VPS52 WWTR1	3 interacting genes: CYREN NEK6 TCP11L1
Entrez ID		55346	375748
HPRD ID		07750	17362
Ensembl ID		ENSG00000176148	ENSG00000182150
Uniprot IDs		B3KQZ4 Q9NUJ3	A0A590UJ12 A0A590UJA1 A0A590UJK0 A0A5F9UKL4 A0A804HJ75 A0A804HK79 A0AAQ5BIG0 Q5T890
PDB IDs			6HQ9 8COB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telencephalon Regionalization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process HMG Box Domain Binding Regulation Of Neuron Differentiation Transcription Corepressor Activity Positive Regulation Of Metabolic Process Negative Regulation Of Post-translational Protein Modification DNA Binding Sequence-specific DNA Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Chromatin Protein-containing Complex Regulation Of Primary Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Formation Of Structure Involved In A Symbiotic Process Forebrain-midbrain Boundary Formation Signal Transduction Involved In Regulation Of Gene Expression
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