CNTF and TIMM10

		CNTF	TIMM10
Description		ciliary neurotrophic factor	translocase of inner mitochondrial membrane 10
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Axon Neuronal Cell Body Glial Cell Projection	Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Intermembrane Space Membrane Mitochondrial Intermembrane Space Chaperone Complex TIM22 Mitochondrial Import Inner Membrane Insertion Complex
	Molecular Function	Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Protein-containing Complex Binding	Protein Binding Zinc Ion Binding Membrane Insertase Activity Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Astrocyte Activation Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Axon Regeneration Retinal Rod Cell Differentiation Ciliary Neurotrophic Factor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT	Protein Targeting To Mitochondrion Sensory Perception Of Sound Protein Transport Protein Insertion Into Mitochondrial Inner Membrane
Pathways		IL-6-type cytokine receptor ligand interactions	Mitochondrial protein import Mitochondrial protein import Mitochondrial protein degradation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 23128233) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908)	Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		16 interacting genes: AK8 APOE CNTFR CYSRT1 IL6R IL6ST KRT31 KRT40 LIFR NDUFAB1 RDM1 S100A1 S100A6 S100P TEPSIN TRIP6	3 interacting genes: - TBC1D21 ZNF655
Entrez ID		1270	26519
HPRD ID		00347	03768
Ensembl ID		ENSG00000242689	ENSG00000134809
Uniprot IDs		P26441	P62072
PDB IDs		1CNT 8D74	2BSK 7CGP
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor Receptor Activity Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Complex Interleukin-11 Receptor Activity Interleukin-11 Binding Interleukin-11-mediated Signaling Pathway Cytokine Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Interleukin-6 Receptor Complex Oncostatin-M Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine Binding Ciliary Neurotrophic Factor Receptor Binding Regulation Of Platelet Activation Interleukin-6 Receptor Binding Structural Molecule Activity Protein Homodimerization Activity Positive Regulation Of Platelet Aggregation Calcium-dependent Protein Binding T-helper 17 Cell Lineage Commitment S100 Protein Binding Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment External Side Of Plasma Membrane Regulation Of Platelet Aggregation T Cell Lineage Commitment Cytokine-mediated Signaling Pathway Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Receptor Complex Ciliary Neurotrophic Factor Binding Growth Factor Binding Acyl Carrier Activity Coated Vesicle Membrane Vasodilation Structural Constituent Of Skin Epidermis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Presynaptic Membrane Organization	Aldehyde Metabolic Process Positive Regulation Of Deacetylase Activity Glycerone Kinase Activity Triokinase Activity FAD-AMP Lyase (cyclizing) Activity Retrograde Trans-synaptic Signaling By Endocannabinoid Monoacylglycerol Biosynthetic Process Cannabinoid Biosynthetic Process Diacylglycerol Catabolic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Metabolic Process Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione CCR1 Chemokine Receptor Binding Release From Viral Latency Glycerol Catabolic Process Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Negative Regulation Of MDA-5 Signaling Pathway Sperm Mitochondrial Sheath Assembly Varicosity Muscle Organ Morphogenesis Lipoprotein Lipase Activity Positive Regulation Of Axon Regeneration Retinal Rod Cell Differentiation CAMP Response Element Binding Protein Binding Plasma Membrane To Endosome Transport Monoacylglycerol Lipase Activity Glyceraldehyde-3-phosphate Metabolic Process
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