SHE and DOK3

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		SHE	DOK3
Description		Src homology 2 domain containing E	docking protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytoplasm Plasma Membrane Membrane Secretory Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding	Protein Binding
	Biological Process		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798)	Coronary artery disease ( 29212778) Inflammatory bowel disease ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: ABL1 AR DOK3 EGFR FHL3 TRIT1	31 interacting genes: A1CF ABL1 ANKS1A APPL1 APPL2 COX5B CRK CSK DOK1 DOK2 DOK5 DTX2 FYN GCM2 HOXA1 INPP5D LCK LYN MDFI PLEKHA3 PPIH PRKAB2 RBPMS RET RIN3 SHC3 SHE SPAG8 STAT3 TNS2 TRAF1
Entrez ID		126669	79930
HPRD ID		17293	16834
Ensembl ID		ENSG00000169291	ENSG00000146094
Uniprot IDs		Q5VZ18	A0A6M4C8X9 D6RAM3 Q7L591
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Morphogenesis Of An Epithelial Fold Enzyme-linked Receptor Protein Signaling Pathway MAPK Cascade Positive Regulation Of Morphogenesis Of An Epithelium Intracellular Signaling Cassette Positive Regulation Of Fibroblast Proliferation ERBB Signaling Pathway Regulation Of Morphogenesis Of A Branching Structure Enzyme Binding Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Protein Localization To Cytoplasmic Microtubule Plus-end Regulation Of Morphogenesis Of An Epithelium Cellular Response To Lipid ATPase Binding Prostate Induction Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Male Somatic Sex Determination Multivesicular Body, Internal Vesicle Lumen TRNA Dimethylallyltransferase Activity Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Transitional One Stage B Cell Differentiation Animal Organ Development Podocyte Apoptotic Process DN4 Thymocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Regulation Of Protein Localization To Plasma Membrane Shc-EGFR Complex Regulation Of Growth Positive Regulation Of Mitotic Cell Cycle Nicotinate-nucleotide Adenylyltransferase Activity Protein Localization To Microtubule Plus-end Positive Regulation Of Wnt Signaling Pathway Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Microspike Assembly B-1 B Cell Homeostasis Positive Regulation Of Establishment Of T Cell Polarity Cell Population Proliferation Neuropilin Signaling Pathway	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Protein Tyrosine Kinase Activity Antigen Receptor-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Signal Transduction T Cell Costimulation T Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Hepatocyte Growth Factor Positive Regulation Of Macropinocytosis Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of MAPK Cascade Regulation Of Endocytosis CD8 Receptor Binding Positive Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Immune Response Cytosol Positive Regulation Of Lymphocyte Activation Regulation Of Phagocytosis Identical Protein Binding Regulation Of Toll-like Receptor 4 Signaling Pathway Macropinosome Immune Response-activating Signaling Pathway Negative Regulation Of Immune System Process Cytoplasm Regulation Of Cell Migration Regulation Of Vesicle-mediated Transport Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway SH2 Domain Binding Leukocyte Migration Regulation Of Immune System Process Regulation Of Cell Motility Positive Regulation Of Cell Activation Positive Regulation Of Pinocytosis Regulation Of Signal Transduction Regulation Of Locomotion
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