CMTM3 and DHX38

		CMTM3	DHX38
Description		CKLF like MARVEL transmembrane domain containing 3	DEAH-box helicase 38
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Membrane Cytoplasmic Vesicle Nuclear Membrane	Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Cytokine Activity Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity
	Biological Process	Blastocyst Hatching Chemotaxis Signal Transduction Positive Regulation Of B Cell Receptor Signaling Pathway	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS			Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 23696881) Cholesterol, total ( 20686565 25961943) Coronary artery disease ( 29212778) Depression ( 29700475) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) LDL cholesterol ( 20686565 25961943) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 22916037) Red blood cell count ( 32888494) Serum metabolite levels (CMS) ( 31636271) Urate levels ( 31578528)
Interacting Genes		30 interacting genes: APOA5 APP AQP6 ARL13B BLNK BTK CREB3L1 ELOVL4 GJB1 GPR35 HSD17B11 IKBIP IL10RA LEUTX LMNA LRRC59 MAPK1 MEST MOB1A MOB3C MRM1 RABAC1 REEP4 RETREG3 SLC10A1 SLC71A2 SPP1 STMN4 SYT2 VEZT	8 interacting genes: CDC40 CSNK2A1 MFAP1 PPP4C RNF10 SNRNP200 U2AF1 WBP4
Entrez ID		123920	9785
HPRD ID		16259	05720
Ensembl ID		ENSG00000140931	ENSG00000140829
Uniprot IDs		H3BUD5 J3KSR6 Q96MX0	Q92620
PDB IDs			5YZG 6ZYM 7A5P 8I0W
Enriched GO Terms of Interacting Partners?			MRNA Metabolic Process MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Processing U2-type Precatalytic Spliceosome RNA Metabolic Process Nucleic Acid Metabolic Process Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Binding Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cytoplasmic Translational Fidelity Response To Injury Involved In Regulation Of Muscle Adaptation Negative Regulation Of Muscle Atrophy Chromatin Loop Anchoring Activity Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) Vitamin A Biosynthetic Process Beta-carotene Metabolic Process Nucleus Peptide Lactyltransferase (ATP-dependent) Activity Macromolecule Metabolic Process Ser-tRNA(Ala) Deacylase Activity Cis Assembly Of Pre-catalytic Spliceosome Carotene Metabolic Process Carotenoid Dioxygenase Activity Carotene Catabolic Process Nucleic Acid Binding
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