IGF2BP3 and NFATC3

Number of citations of the paper that reports this interaction (PubMedID 37340423)
55

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		IGF2BP3	NFATC3
Description		insulin like growth factor 2 mRNA binding protein 3	nuclear factor of activated T cells 3
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Regulator Activity MRNA 5'-UTR Binding N6-methyladenosine-containing RNA Reader Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Cytokine Production Translation Regulation Of Translation Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Translation MRNA Transport CRD-mediated MRNA Stabilization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Calcineurin-NFAT Signaling Cascade Positive Thymic T Cell Selection Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription DN4 Thymocyte Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Artery Morphogenesis
Pathways		Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Height ( 20881960 23563607 25282103 28552196) Hip circumference adjusted for BMI ( 25673412 34021172) Infant length ( 25281659) Offspring birth weight ( 31043758) Personality dimensions ( 23903073) Tau burden ( 33426524) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)	Chronotype ( 30696823) Estimated glomerular filtration rate ( 31015462) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528)
Interacting Genes		86 interacting genes: ANXA1 CEBPA DUX4 FOXP1 MEOX2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MKRN2 NEIL3 NFATC3 OGT PCBP1 PIH1D2 UBXN7 USP7 WEE2-AS1	7 interacting genes: CDK6 CSNK1A1 FOS IGF2BP3 MAPK8 MAPK9 TTF1
Entrez ID		10643	4775
HPRD ID		16306	04077
Ensembl ID		ENSG00000136231	ENSG00000072736
Uniprot IDs		O00425	B5B2S0 B5B2S1 Q12968
PDB IDs		2E44 6FQ1 6FQR 6GQE 6GX6	2XRW 2XS0
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Negative Regulation Of Cell Migration Regulation Of Macromolecule Metabolic Process RNA Destabilization Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Developmental Process Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Translation Regulation Of MRNA Stability Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Regulation Of Locomotion Negative Regulation Of Signal Transduction Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Space	JUN Kinase Activity Parallel Fiber To Purkinje Cell Synapse Protein Serine Kinase Activity NLRP3 Inflammasome Complex Assembly Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway MAP Kinase Activity Protein Serine/threonine Kinase Activity R-SMAD Binding Response To Reactive Oxygen Species Positive Regulation Of NLRP3 Inflammasome Complex Assembly Canonical Inflammasome Complex Assembly Protein Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Oxidative Stress Regulation Of MRNA Stability Regulation Of RNA Stability Cyclin D2-CDK6 Complex Medium-term Memory Cellular Response To Prolactin JUN Phosphorylation Positive Regulation Of MiRNA Transcription Fc Receptor Signaling Pathway Cellular Response To Nutrient Levels JNK Cascade Kinase Activity Positive Regulation Of MiRNA Metabolic Process Cellular Response To Chemical Stress Cellular Senescence Dendriole Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding I(KACh) Inward Rectifier Potassium Channel Complex Protein Localization To Tricellular Tight Junction Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of MiRNA Transcription Nucleus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Neural Plate Anterior/posterior Regionalization Response To Prolactin Conditioned Taste Aversion Regulation Of MiRNA Metabolic Process Regulation Of MRNA Metabolic Process Termination Of RNA Polymerase I Transcription Regulation Of Cell Growth By Extracellular Stimulus Protein Phosphorylation
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