IGF2BP3 and MIRLET7F2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		IGF2BP3	MIRLET7F2
Description		insulin like growth factor 2 mRNA binding protein 3	microRNA let-7f-2
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule	RISC Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Regulator Activity MRNA 5'-UTR Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	Regulation Of Cytokine Production Translation Regulation Of Translation Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Translation MRNA Transport CRD-mediated MRNA Stabilization	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Height ( 20881960 23563607 25282103 28552196) Hip circumference adjusted for BMI ( 25673412 34021172) Infant length ( 25281659) Offspring birth weight ( 31043758) Personality dimensions ( 23903073) Tau burden ( 33426524) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)	Bipolar disorder ( 31043756)
Interacting Genes		86 interacting genes: ANXA1 CEBPA DUX4 FOXP1 MEOX2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MKRN2 NEIL3 NFATC3 OGT PCBP1 PIH1D2 UBXN7 USP7 WEE2-AS1	95 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B ATXN2L C1QBP CPSF1 CPSF2 CPSF6 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PLOD1 PRMT1 PTBP1 PTCD3 PUF60 PUM1 PUM2 PURA RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2B TRIM71 TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		10643	406889
HPRD ID		16306
Ensembl ID		ENSG00000136231	ENSG00000208012
Uniprot IDs		O00425
PDB IDs		2E44 6FQ1 6FQR 6GQE 6GX6
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Negative Regulation Of Cell Migration Regulation Of Macromolecule Metabolic Process RNA Destabilization Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Developmental Process Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Translation Regulation Of MRNA Stability Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Regulation Of Locomotion Negative Regulation Of Signal Transduction Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Space	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process MRNA Processing Nucleobase-containing Compound Metabolic Process RNA Splicing MRNA Binding Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process MiRNA Binding Nucleus Regulation Of RNA Splicing Ribonucleoprotein Complex Nucleoplasm Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of Translation Cytoplasmic Stress Granule MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Catalytic Step 2 Spliceosome Regulation Of RNA Stability Regulation Of MRNA Stability MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Spliceosomal Complex MiRNA Processing Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Processing RNA 3'-end Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Translation Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process RNA Stabilization Negative Regulation Of Macromolecule Metabolic Process MRNA Stabilization Negative Regulation Of Gene Expression Negative Regulation Of Metabolic Process Positive Regulation Of Cytoplasmic Translation TRNA Metabolic Process Paraspeckles Nucleolus
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