SFXN2 and REEP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SFXN2	REEP4
Description		sideroflexin 2	receptor accessory protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Microtubule Cytoplasmic Microtubule Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding Monoatomic Ion Transmembrane Transporter Activity Transmembrane Transporter Activity	Protein Binding Microtubule Binding
	Biological Process	Monoatomic Ion Transport Amino Acid Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Serine Import Into Mitochondrion Mitochondrial Transmembrane Transport	Nuclear Envelope Organization Mitotic Nuclear Membrane Reassembly Cell Division Endoplasmic Reticulum Tubular Network Organization
Pathways
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Carotid plaque burden ( 28282560) Feeling tense ( 29500382) Hip circumference adjusted for BMI ( 34021172) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Schizophrenia ( 23974872 25056061) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 27863252)	Frailty index ( 34431594) Hypertriglyceridemia ( 23505323)
Interacting Genes		5 interacting genes: AQP6 HSD17B13 PDZK1IP1 REEP4 TMEM14B	101 interacting genes: AGPAT4 ARLN BCL2L1 BET1 BIK BMP10 C14orf180 C1S C2CD2L CCL4L2 CLDND2 CMTM3 COMT CTSA CYB5B CYB5R3 CYP4F2 DCBLD2 DERL1 DGAT2L6 DNAJC30 ERG28 FAM241B FBXO7 FMO1 FUNDC2 GIMAP1 GYPB HSD3B7 HTATIP2 IFITM3 ITGAM LEMD1 LEMD3 LEPROTL1 LNPEP MAL2 MOSPD3 MS4A1 NCK2 NINJ2 ORMDL1 PEX16 PLP2 PMP22 PRAF2 RTP2 RTP4 SEC22B SELENOK SELENOM SERF1A SERF1B SERP1 SFT2D1 SFT2D2 SFXN2 SFXN3 SLC25A46 SLC30A8 SLC7A8 SMAGP SMIM1 SQLE STATH STX3 STX5 SYNJ2BP TIMM22 TMEM120B TMEM121 TMEM128 TMEM14B TMEM167B TMEM18 TMEM19 TMEM208 TMEM229B TMEM254 TMEM42 TMEM50A TMEM51 TMEM60 TMEM65 TMEM86A TMX2 TPRG1 TSNARE1 TSPAN2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP4 VAPB VMA12 VTI1B YIF1A YIPF4 YIPF6
Entrez ID		118980	80346
HPRD ID		18045	09864
Ensembl ID		ENSG00000156398	ENSG00000168476
Uniprot IDs		A0A0C4DGR6 Q96NB2	E5RGS2 Q9H6H4
PDB IDs
Enriched GO Terms of Interacting Partners?		PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Steroid Dehydrogenase Activity Monoatomic Anion Channel Activity Carbon Dioxide Transmembrane Transporter Activity Ammonium Transmembrane Transport Ammonium Channel Activity Renal Water Transport Carbon Dioxide Transmembrane Transport Mitotic Nuclear Membrane Reassembly Regulation Of Lysosome Size Response To Cycloheximide BORC Complex Regulation Of Endosome Size Cytoplasmic Side Of Lysosomal Membrane Water Channel Activity Carbon Dioxide Transport Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Regulation Of Vesicle Size One-carbon Compound Transport Water Transport Endoplasmic Reticulum Tubular Network Nuclear Membrane Reassembly Nuclear Envelope Organization Endoplasmic Reticulum Tubular Network Organization Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Motor Behavior	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Endomembrane System SNAP Receptor Activity SNARE Complex Protein Binding Establishment Of Protein Localization Organelle Fusion Vesicle Fusion Organelle Membrane Fusion Mitochondrial Outer Membrane Membrane Fusion Membrane Organization Vesicle Fusion With Golgi Apparatus Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Docking Protein Transport Presynaptic Endosome Membrane Golgi Vesicle Transport Monoatomic Ion Transmembrane Transporter Activity Intracellular Transport Cellular Localization Mitochondrial Membrane Nitric-oxide Synthase Complex Vesicle Organization Organelle Localization By Membrane Tethering Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Serine Import Into Mitochondrion Olfactory Receptor Binding Establishment Of Localization In Cell Myelination Axon Ensheathment Nitrite Reductase (NO-forming) Activity Transport Vesicle Golgi Membrane Vesicle Docking Menaquinone Metabolic Process SNARE Binding Golgi Organization Import Into The Mitochondrion Bcl-2 Family Protein Complex Mitochondrial Transport
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