SFXN2 and PDZK1IP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SFXN2	PDZK1IP1
Description		sideroflexin 2	PDZK1 interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Monoatomic Ion Transmembrane Transporter Activity Transmembrane Transporter Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Amino Acid Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Serine Import Into Mitochondrion Mitochondrial Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Carotid plaque burden ( 28282560) Feeling tense ( 29500382) Hip circumference adjusted for BMI ( 34021172) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Schizophrenia ( 23974872 25056061) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 27863252)	Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		5 interacting genes: AQP6 HSD17B13 PDZK1IP1 REEP4 TMEM14B	77 interacting genes: AGR3 AIG1 APOA2 APOD AQP2 AQP6 ARL13B ASGR1 C14orf180 C2CD2L CD81 CES1 CLDN19 COPS6 CYB5B CYBC1 EMC6 ERG28 FAM3C FCER1G GALNT15 GAST GIMAP5 GRM2 GYPA HMOX1 ICMT IGFBP5 JAGN1 LEPROTL1 LHFPL5 MIP MYADM MYADML2 NSG1 NUMB PDZK1 PEX16 PGAP2 PLP2 PLPP4 PLPP6 PMP22 RPRM RTP2 SDCBP SFTPC SFXN2 SLC22A1 SLC22A2 SLC35B1 SLC35B4 STRIT1 STX12 THBD TMEM101 TMEM107 TMEM109 TMEM11 TMEM140 TMEM14A TMEM14B TMEM14C TMEM203 TMEM39B TMEM65 TMEM86A TMEM97 TNFRSF10C TRARG1 TRIM54 TSPO2 UPK1B UTP14A VAMP3 YIPF6 ZDHHC17
Entrez ID		118980	10158
HPRD ID		18045	06211
Ensembl ID		ENSG00000156398	ENSG00000162366
Uniprot IDs		A0A0C4DGR6 Q96NB2	Q13113
PDB IDs			7VSI 7WMV 7YNI 7YNJ 7YNK 8HB0 8HDH 8HEZ 8HG7 8HIN
Enriched GO Terms of Interacting Partners?		PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Steroid Dehydrogenase Activity Monoatomic Anion Channel Activity Carbon Dioxide Transmembrane Transporter Activity Ammonium Transmembrane Transport Ammonium Channel Activity Renal Water Transport Carbon Dioxide Transmembrane Transport Mitotic Nuclear Membrane Reassembly Regulation Of Lysosome Size Response To Cycloheximide BORC Complex Regulation Of Endosome Size Cytoplasmic Side Of Lysosomal Membrane Water Channel Activity Carbon Dioxide Transport Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Regulation Of Vesicle Size One-carbon Compound Transport Water Transport Endoplasmic Reticulum Tubular Network Nuclear Membrane Reassembly Nuclear Envelope Organization Endoplasmic Reticulum Tubular Network Organization Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Motor Behavior	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Localization Within Membrane Organic Hydroxy Compound Transport Protein Binding Cholesterol Binding Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Protein Localization To Membrane Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Cellular Response To Lipoprotein Particle Stimulus Quaternary Ammonium Group Transport Water Channel Activity Cellular Localization Organic Cation Transport Putrescine Transmembrane Transporter Activity Lipid Transport Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Transmembrane Transport Water Transport Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Protein Localization To Plasma Membrane Cholesterol Transport Monoamine Transport Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Cellular Response To Low-density Lipoprotein Particle Stimulus Carnitine Transmembrane Transport Carnitine Transport Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Sterol Transport Regulation Of Transport Renal Water Transport Fluid Transport Heme Metabolic Process Serotonin Uptake Norepinephrine Transport Neutrophil Differentiation
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