CLCN3 and FZD3

Data Source: HiPPIP (Novel)

		CLCN3	FZD3
Name		chloride voltage-gated channel 3	frizzled class receptor 3
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Vesicle Membrane Membrane Secretory Granule Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Ruffle Membrane Specific Granule Cell Projection Axon Terminus Phagocytic Vesicle Recycling Endosome Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Dendrite Filopodium Tip Neuronal Cell Body Apical Part Of Cell Presynaptic Active Zone Presynaptic Active Zone Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity PDZ Domain Binding Chloride:proton Antiporter Activity Volume-sensitive Chloride Channel Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Regulation Of PH Phagocytosis, Engulfment Adult Locomotory Behavior Synaptic Transmission, Glutamatergic Photoreceptor Cell Maintenance Negative Regulation Of Cell Volume Endosomal Lumen Acidification Synaptic Transmission, GABAergic Transmembrane Transport Neuron Cellular Homeostasis Synaptic Vesicle Lumen Acidification Chloride Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Positive Regulation Of Neuroblast Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Response To Xenobiotic Stimulus Wnt Signaling Pathway Neuron Differentiation Midbrain Development Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Inner Ear Morphogenesis Negative Regulation Of Mitotic Cell Cycle, Embryonic Response To Electrical Stimulus Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Sympathetic Ganglion Development Commissural Neuron Axon Guidance Motor Neuron Migration Negative Regulation Of Execution Phase Of Apoptosis Midbrain Morphogenesis
Pathways		Stimuli-sensing channels	Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Asymmetric localization of PCP proteins
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Schizophrenia ( 25056061 28991256 29483656 30285260 )	No GWAS studies recorded
Novel Interactors		11 novel interactors: ANXA10 DECR1 ETFDH FZD3 GPRC5C GRIA2 HPF1 MED23 NEK1 PDGFB VPS18	2 novel interactors: ADORA2A CLCN3
Interacting Genes		6 interacting genes: CFTR DNAJC5 GOPC HSPB1 NHERF1 PDZK1	3 interacting genes: GIPC1 GIPC2 GIPC3
Entrez ID		1182	7976
HPRD ID		02785	05849
Ensembl ID		ENSG00000109572	ENSG00000104290
Uniprot IDs		B3KXK0 E9PE15 P51790	Q9NPG1
PDB IDs		Not available	8JHC 8JHI 8Q7O 8QW4
GO Terms Enriched among Interactors		Regulation Of Monoatomic Anion Transport PDZ Domain Binding Chloride Channel Regulator Activity Regulation Of Monoatomic Ion Transport Golgi-associated Vesicle Membrane 14-3-3 Protein Binding Apical Plasma Membrane Regulation Of Transport Lysosomal Membrane Microvillus Membrane Protein-membrane Adaptor Activity Vesicle Docking Involved In Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Protein Kinase C Signaling Metanephric Glomerular Mesangial Cell Development Renal Phosphate Ion Absorption Negative Regulation Of Anion Channel Activity	Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Transmission, Glutamatergic Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Vesicle Membrane Glutamatergic Synapse Cell-cell Signaling Cell Communication Signaling Synaptic Vesicle Chloride:proton Antiporter Activity Positive Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Synaptic Plasticity Locomotory Behavior G Protein-coupled Adenosine Receptor Activity Type 5 Metabotropic Glutamate Receptor Binding Negative Regulation Of Cell Volume Volume-sensitive Chloride Channel Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Norepinephrine Secretion Synaptic Transmission, Dopaminergic Prepulse Inhibition Inhibitory Postsynaptic Potential Positive Regulation Of Urine Volume Asymmetric Synapse Positive Regulation Of Glutamate Secretion Axolemma Alpha-actinin Binding Response To Caffeine G Protein-coupled Adenosine Receptor Signaling Pathway Specific Granule Endosomal Lumen Acidification Voltage-gated Chloride Channel Activity Cellular Response To Interleukin-7 Regulation Of Melanin Biosynthetic Process Response To Interleukin-7 Positive Regulation Of Melanin Biosynthetic Process Glutamate Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Circadian Rhythm Regulation Of Urine Volume Astrocyte Activation Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Vascular Permeability Chloride Transmembrane Transporter Activity