AGAP1 and SP110

		AGAP1	SP110
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	SP110 nuclear body protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Endosome	Nucleus Nucleoplasm Nuclear Lumen
	Molecular Function	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Zinc Ion Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Transport Regulation Of Modification Of Postsynaptic Structure	Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Anterior thalamic nuclei volume ( 34006833) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Chronic lymphocytic leukemia ( 18758461 24292274 28165464) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		16 interacting genes: APP ARF1 ARF6 CDC42 DYRK1A GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA RSPH14 SMN1 SRC TK1 WEE2-AS1 ZNF534	11 interacting genes: ANXA7 CDKN1A NAP1L2 NDUFV2 OSGEP RUNX3 SMN1 TK1 TSC22D1 TTR ZSCAN9
Entrez ID		116987	3431
HPRD ID		16359	06832
Ensembl ID		ENSG00000157985	ENSG00000135899
Uniprot IDs		B2RZG9 E7EUN2 Q9UPQ3	A0A8V8TN67 Q9HB58
PDB IDs		7EB6
Enriched GO Terms of Interacting Partners?		Regulation Of Supramolecular Fiber Organization GTP Binding Membrane Invagination Thioesterase Binding Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Regulation Of Endocytosis G Protein Activity Regulation Of Cell-substrate Junction Organization Guanylate Cyclase Complex, Soluble Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Establishment Of Epithelial Cell Polarity Positive Regulation Of Locomotion Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Neuron Projection Organization Regulation Of Receptor-mediated Endocytosis Cell Junction Organization Regulation Of Actin Filament Organization Positive Regulation Of Cytokinesis Negative Regulation Of Cellular Component Organization Substrate Adhesion-dependent Cell Spreading Nucleotide Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Synapse Organization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Signaling Receptor Activator Activity Positive Regulation Of Stress Fiber Assembly Guanylate Cyclase Activity Regulation Of Cytoskeleton Organization GTPase Activity Establishment Or Maintenance Of Cell Polarity Circulatory System Process Nitric Oxide-cGMP-mediated Signaling Regulation Of Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Glutamatergic Synapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Podosome Assembly Flavonoid Metabolic Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly
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