GSTCD and TNS4

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		GSTCD	TNS4
Description		glutathione S-transferase C-terminal domain containing	tensin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Anchoring Junction
	Molecular Function	Molecular_function Protein Binding	Actin Binding Protein Binding
	Biological Process	Biological_process Response To Lipopolysaccharide Respiratory System Development	Intracellular Protein Localization
Pathways			MET interacts with TNS proteins
Drugs
Diseases
GWAS		Asthma ( 31959851) Chronic obstructive pulmonary disease ( 28166215) Copper levels ( 26025379) FEV1 ( 30804560) Lung function (FEV1) ( 24023788 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 28166213 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Peak expiratory flow ( 30804560) Post bronchodilator FEV1 ( 26634245) Psoriasis ( 31376382) Pulmonary function ( 20010835 20010834) Pulmonary function (smoking interaction) ( 23284291) Sleep (1/3-day periodicity) ( 33075057)	Asthma ( 31959851) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)
Interacting Genes		7 interacting genes: CLNK DAPP1 KDM1A PRMT6 STAT3 SUV39H2 TNS4	23 interacting genes: AR CARD9 CYSRT1 EGFR ERBB3 ERBB4 GAB1 GSTCD HSF2BP KAZN KCTD4 MET NME4 NR3C1 P4HA2 PIH1D1 PIK3R1 RABEP1 RPAIN TRIM21 TRIM27 TXK ZRANB1
Entrez ID		79807	84951
HPRD ID		07823	12223
Ensembl ID		ENSG00000138780	ENSG00000131746
Uniprot IDs		B7Z8J7 Q8NEC7	Q6PJP3 Q8IZW8
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Transcription Regulator Complex Interleukin-10-mediated Signaling Pathway RNA Sequestering Activity Negative Regulation Of Primary MiRNA Processing Cellular Response To Leptin Stimulus Regulation Of Cell Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Postsynapse To Nucleus Signaling Pathway Interleukin-9-mediated Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Interleukin-11-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Protein-containing Complex Retinal Rod Cell Differentiation Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Cellular Response To Interleukin-17 Interleukin-15-mediated Signaling Pathway Negative Regulation Of MiRNA Processing T-helper 17 Type Immune Response Negative Regulation Of Inflammatory Response To Wounding Primary MiRNA Binding DNA-binding Transcription Factor Binding Leptin-mediated Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation CCR5 Chemokine Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3K9 Demethylase Activity Response To Fungicide MRF Binding Histone H3K4 Demethylase Activity Guanine Metabolic Process Protein Demethylase Activity Chromatin Remodeling Telomeric Repeat-containing RNA Binding Regulation Of Signal Transduction By P53 Class Mediator FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Chromatin Organization Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine N-methyltransferase Activity	Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Basal Plasma Membrane Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process ErbB-3 Class Receptor Binding Positive Regulation Of Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Epithelial Cell Proliferation Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Eyelid Development In Camera-type Eye Receptor Complex Morphogenesis Of An Epithelial Fold Kinase Activity Negative Regulation Of Programmed Cell Death ATPase Binding Protein Tyrosine Kinase Activator Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Viral Transcription Mammary Gland Alveolus Development Suppression Of Viral Release By Host Regulation Of MiRNA Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Positive Regulation Of Metabolic Process Regulation Of Cell Communication Positive Regulation Of Multicellular Organismal Process
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