SERTAD2 and ESPNL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SERTAD2	ESPNL
Description		SERTA domain containing 2	espin like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Stereocilium Stereocilium Tip Cell Projection
	Molecular Function	Transcription Coactivator Activity Protein Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Cell Growth Positive Regulation Of DNA-templated Transcription	Sensory Perception Of Sound Actin Filament Bundle Assembly
Pathways			Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Antisaccade task score ( 31596458) Apolipoprotein B levels ( 32203549) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 28957414 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) TPE interval (resting) ( 32386560) Visceral fat ( 22589738)
Interacting Genes		25 interacting genes: AIRIM ATG12 CDC7 CKS1B CREBBP CTNNA3 E2F1 ESPNL HELLS IGFN1 KAT2B KAT5 PARVG PIK3R3 PLA2G6 PRKAB2 STRA8 SUPT7L TFDP1 TNS2 TRIM28 XPO1 ZNF524 ZNF581 ZSCAN22	3 interacting genes: LDLRAP1 PFDN5 SERTAD2
Entrez ID		9792	339768
HPRD ID		18040	14170
Ensembl ID		ENSG00000179833	ENSG00000144488
Uniprot IDs		Q14140	B3KXY4 Q6ZVH7
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Binding Peptidyl-lysine Acetylation Acetyltransferase Activity Histone Acetyltransferase Complex N-terminal Peptidyl-lysine Acetylation Protein-lysine-acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of DNA Metabolic Process Histone Acetyltransferase Activity Protein Acetylation Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Regulation Of DNA Repair Positive Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Recombinational Repair Transcription Coactivator Activity Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Process Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore N-terminal Protein Amino Acid Acetylation Anoikis Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Regulation Of Metaphase Plate Congression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm Double-strand Break Repair Attachment Of Mitotic Spindle Microtubules To Kinetochore Transcription Regulator Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Recombination Positive Regulation Of Lipid Biosynthetic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore SAGA Complex Protein Kinase Binding Cellular Response To Nutrient Levels Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Phosphatidylethanolamine Metabolic Process Chromatin Binding DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Chromosome Segregation Protein Binding	RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly Amyloid-beta Binding Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Intracellular Cholesterol Transport Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Intracellular Lipid Transport AP-1 Adaptor Complex Binding Prefoldin Complex Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport AP-2 Adaptor Complex Binding Neurofilament Negative Regulation Of Amyloid Fibril Formation Low-density Lipoprotein Particle Clearance Regulation Of Cellular Component Organization Regulation Of Amyloid Fibril Formation Clathrin Adaptor Activity Regulation Of Low-density Lipoprotein Particle Clearance Amyloid Precursor Protein Metabolic Process Low-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Metabolic Process Signaling Receptor Complex Adaptor Activity Clathrin Binding Positive Regulation Of Cholesterol Transport Regulation Of Protein Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Steroid Metabolic Process Intermediate Filament Cytoskeleton Phosphotyrosine Residue Binding Regulation Of Cholesterol Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis
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