KLHDC3 and ENAH

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		KLHDC3	ENAH
Name		kelch domain containing 3	ENAH actin regulator
Structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium Filopodium Cell Projection Synapse Anchoring Junction Postsynapse GABA-ergic Synapse
	Molecular Function	Chromatin Binding Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Protein Domain Specific Binding WW Domain Binding
	Biological Process	Reciprocal Meiotic Recombination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Meiotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Axon Guidance Actin Polymerization Or Depolymerization Actin Polymerization-dependent Cell Motility Postsynaptic Cytoskeleton Organization
Pathways		XBP1(S) activates chaperone genes	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors
GWAS		No GWAS studies recorded	Delirium ( 29631748 ) Depression in smokers ( 30219690 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Neuroticism ( 27067015 ) Obesity-related traits ( 23251661 )
Novel Interactors		3 novel interactors: DRC5 HLA-DQA1 RSPH9	1 novel interactors: DNAH14
Interacting Genes		2 interacting genes: ENAH UBC	27 interacting genes: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP EVL FAT1 FYB1 GPHN HMGB1 KLHDC3 MAPK1 PFN1 PRPF40A RAC1 RAD51 ROBO4 SPTA1 TERF2IP TES VASP WAS XIRP1 YAP1 ZYX
Entrez ID		116138	55740
HPRD ID		13922	12360
Ensembl ID		ENSG00000124702	ENSG00000154380
Uniprot IDs		Q9BQ90	A0A097PIC4 A0A097PID1 A0A4D6J698 Q8N8S7
PDB IDs		9D1I 9D1Y 9D1Z	2HO2 2IYB 2XQN 4MY6 5N91 5N9C 5N9P 5NAJ 5NBF 5NBX 5NC2 5NC7 5NCF 5NCG 5NCP 5ND0 5NDU 5NEG 6RCF 6RCJ 6RD2 6XVT 6XXR 7A5M 7AKI 7LXE 9C66
GO Terms Enriched among Interactors		Endocytic Vesicle Membrane Sperm Flagellum Cilium Movement Cilium Movement Involved In Cell Motility Radial Spoke Head 1 Radial Spoke Assembly Radial Spoke Head 3 Motile Cilium Axonemal Central Apparatus Assembly Radial Spoke Head Actin Polymerization-dependent Cell Motility Endosome Membrane MHC Class II Receptor Activity Kinocilium Profilin Binding Cell Projection Radial Spoke Peptide Antigen Assembly With MHC Class II Protein Complex Protein Tag Activity MHC Class II Protein Complex Microtubule-based Movement Cytoskeleton Postsynaptic Cytoskeleton Organization WW Domain Binding MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II 9+2 Motile Cilium Peptide Antigen Binding Cilium	Actin Filament Organization Actin Polymerization Or Depolymerization Supramolecular Fiber Organization Lamellipodium Cytoskeleton Proline-rich Region Binding Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Anchoring Junction Actin Filament-based Process Regulation Of Organelle Organization Positive Regulation Of Actin Filament Polymerization Focal Adhesion Positive Regulation Of Cytoskeleton Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Filament Polymerization Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Organelle Organization Actin Cytoskeleton Organization Regulation Of Cell Projection Assembly Regulation Of Cellular Component Size Regulation Of Ruffle Assembly Filopodium Actin-based Cell Projection Actin Cytoskeleton Positive Regulation Of Protein Polymerization Regulation Of Protein-containing Complex Assembly Regulation Of Lamellipodium Assembly Regulation Of Stress Fiber Assembly SCAR Complex SH3 Domain Binding Negative Regulation Of Cellular Component Organization Cytoplasm Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Postsynapse Cytoskeleton Organization Regulation Of Cell Motility Regulation Of Cell Shape Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Locomotion Cell Projection Morphogenesis Regulation Of Anatomical Structure Morphogenesis