CKMT2 and P4HA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CKMT2	P4HA3
Description		creatine kinase, mitochondrial 2	prolyl 4-hydroxylase subunit alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Nucleotide Binding Catalytic Activity Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Muscle Contraction Phosphocreatine Biosynthetic Process	Collagen Fibril Organization
Pathways		Creatine metabolism	Collagen biosynthesis and modifying enzymes
Drugs		Creatine Phosphocreatine
Diseases
GWAS			Hippocampal atrophy ( 25625606)
Interacting Genes		10 interacting genes: ABHD6 CETN3 ELN KLHL42 LRIF1 NRF1 OLFML3 P4HA3 TMED9 UNC119	49 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A FIRRM GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZC3H12A
Entrez ID		1160	283208
HPRD ID		00425	16413
Ensembl ID		ENSG00000131730	ENSG00000149380
Uniprot IDs		P17540	Q7Z4N8
PDB IDs		4Z9M
Enriched GO Terms of Interacting Partners?			Protein Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Acetylation Gamma-tubulin Binding
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