FCRL3 and MS4A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FCRL3	MS4A1
Description		Fc receptor like 3	membrane spanning 4-domains A1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Microvillus Membrane Cell Projection	Extracellular Space Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Plasma Membrane Raft Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Kinase Binding Phosphatase Binding	Epidermal Growth Factor Receptor Binding Protein Binding Immunoglobulin Binding MHC Class II Protein Complex Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Immune Response Cell Surface Receptor Signaling Pathway Single Fertilization Positive Regulation Of B Cell Proliferation Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of B Cell Differentiation Negative Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Regulation Of Calcium Ion Import	Store-operated Calcium Entry Humoral Immune Response Cell Surface Receptor Signaling Pathway Response To Bacterium B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway Protein Tetramerization Calcium Ion Import Into Cytosol Positive Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways
Drugs			Rituximab Ibritumomab tiuxetan Tositumomab Ofatumumab Obinutuzumab Technetium Tc-99m nofetumomab merpentan Ublituximab Ocrelizumab Mosunetuzumab Odronextamab
Diseases
GWAS		Blood protein levels ( 30072576) Graves' disease ( 21841780) IgA nephropathy ( 26028593 32912934) Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes ( 21829393) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676) Selective IgA deficiency ( 27723758)	Recurrent major depressive disorder ( 29317602)
Interacting Genes		11 interacting genes: AGPAT4 CMTM5 IGFBP5 MS4A1 PTPN11 PTPN6 SLC2A5 SLC30A3 STATH SYK ZAP70	41 interacting genes: ACKR2 AQP6 CD40 CERS4 CLEC14A CREB3 CREB3L1 CSNK2A1 CSNK2A2 FAM209A FCRL3 FYN GORAB GPR42 HSD17B11 HSD17B13 IL7R KASH5 LCK LEUTX LMNA LYN MDM2 MMD MTIF3 REEP2 REEP4 RNF19B RNF5 SLC10A1 SLC10A6 SLC18A1 SLC35H1 SLC71A2 THAP4 TMEM31 TMEM72 TMEM82 TMPPE TMX2 TSPO2
Entrez ID		115352	931
HPRD ID		07352	00204
Ensembl ID		ENSG00000160856	ENSG00000156738
Uniprot IDs		Q96P31	P11836
PDB IDs			2OSL 3BKY 3PP4 6VJA 6Y90 6Y92 6Y97 6Y9A 8VGN 8VGO
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Neutrophil Activation Involved In Immune Response Leukocyte Activation Neutrophil Activation Beta Selection Cell Activation Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Mediated By Integrin B Cell Activation Lymphocyte Activation Negative Regulation Of Neutrophil Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Proliferation Regulation Of Neutrophil Activation Positive Regulation Of T Cell Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Leukocyte Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway T Cell Receptor Complex Myeloid Leukocyte Activation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Platelet Formation Megakaryocyte Development Positive Regulation Of Alpha-beta T Cell Proliferation Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Regulation Of Lipopolysaccharide-mediated Signaling Pathway T Cell Selection Regulation Of Tumor Necrosis Factor Production Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Developmental Process Regulation Of B Cell Differentiation Positive Regulation Of Cell Adhesion Regulation Of Immune Response Regulation Of Cell Differentiation Regulation Of Cell-cell Adhesion	Membrane Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Protein Kinase CK2 Complex Steroid Dehydrogenase Activity CD8 Receptor Binding Bile Acid:sodium Symporter Activity Fc-gamma Receptor Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lymphocyte Activation Lymphocyte Proliferation Mononuclear Cell Proliferation B Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Costimulation CD4 Receptor Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Endoplasmic Reticulum Endoplasmic Reticulum Membrane Peptidyl-tyrosine Phosphorylation Monocarboxylic Acid Transport Phospholipase Activator Activity Negative Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell Activation Fc Receptor Signaling Pathway Leukocyte Proliferation T Cell Receptor Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of B Cell Proliferation Organic Hydroxy Compound Transport Protein Binding Response To Xenobiotic Stimulus Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Adaptive Immune Response Phosphatidylinositol 3-kinase Binding Negative Regulation Of Apoptotic Process Transmembrane Transport Protein Kinase Activity Negative Regulation Of Programmed Cell Death Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Bile Acid And Bile Salt Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Lymphocyte Activation Nuclear Envelope Organization
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