FCRL3 and AGPAT4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FCRL3	AGPAT4
Description		Fc receptor like 3	1-acylglycerol-3-phosphate O-acyltransferase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Microvillus Membrane Cell Projection	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Kinase Binding Phosphatase Binding	1-acylglycerol-3-phosphate O-acyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Lysophosphatidic Acid Acyltransferase Activity
	Biological Process	Negative Regulation Of Immunoglobulin Production Immune Response Cell Surface Receptor Signaling Pathway Single Fertilization Positive Regulation Of B Cell Proliferation Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of B Cell Differentiation Negative Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Regulation Of Calcium Ion Import	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process CDP-diacylglycerol Biosynthetic Process
Pathways			Synthesis of PA
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Graves' disease ( 21841780) IgA nephropathy ( 26028593 32912934) Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes ( 21829393) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676) Selective IgA deficiency ( 27723758)	Anxiety in major depressive disorder ( 24047446) Diastolic blood pressure ( 30224653) Energy expenditure (24h) ( 28476931) Fear of pain ( 28701861) Lipoprotein (a) - cholesterol levels ( 25575512) Lipoprotein (a) levels ( 26377243) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: AGPAT4 CMTM5 IGFBP5 MS4A1 PTPN11 PTPN6 SLC2A5 SLC30A3 STATH SYK ZAP70	29 interacting genes: AQP12B AQP6 CNR2 CREB3L1 ERGIC3 FCGR2A FCRL3 FFAR2 GPR101 HSD17B11 HSD17B13 JAGN1 LEPROTL1 LEUTX LRRC25 MFF MGST3 REEP4 REL RETREG3 SCN3B SLC10A6 SLC35H1 SLC71A2 SLC7A8 SPACA1 TMEM14B TMEM31 TMX2
Entrez ID		115352	56895
HPRD ID		07352	12437
Ensembl ID		ENSG00000160856	ENSG00000026652
Uniprot IDs		Q96P31	Q9NRZ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Neutrophil Activation Involved In Immune Response Leukocyte Activation Neutrophil Activation Beta Selection Cell Activation Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Mediated By Integrin B Cell Activation Lymphocyte Activation Negative Regulation Of Neutrophil Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Proliferation Regulation Of Neutrophil Activation Positive Regulation Of T Cell Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Leukocyte Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway T Cell Receptor Complex Myeloid Leukocyte Activation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Platelet Formation Megakaryocyte Development Positive Regulation Of Alpha-beta T Cell Proliferation Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Regulation Of Lipopolysaccharide-mediated Signaling Pathway T Cell Selection Regulation Of Tumor Necrosis Factor Production Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Developmental Process Regulation Of B Cell Differentiation Positive Regulation Of Cell Adhesion Regulation Of Immune Response Regulation Of Cell Differentiation Regulation Of Cell-cell Adhesion	Membrane Steroid Dehydrogenase Activity Endoplasmic Reticulum Endoplasmic Reticulum Organization Water Channel Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity
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