FCRL3 and STATH

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		FCRL3	STATH
Name		Fc receptor like 3	statherin
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Microvillus Membrane Cell Projection	Extracellular Region
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Kinase Binding Phosphatase Binding	Protein Binding Extracellular Matrix Constituent, Lubricant Activity Structural Constituent Of Tooth Enamel Hydroxyapatite Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Immune Response Cell Surface Receptor Signaling Pathway Single Fertilization Positive Regulation Of B Cell Proliferation Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of B Cell Differentiation Negative Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Regulation Of Calcium Ion Import	Ossification Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Biomineral Tissue Development Defense Response To Bacterium Saliva Secretion
GWAS		Blood protein levels ( 30072576 ) Graves' disease ( 21841780 ) IgA nephropathy ( 26028593 32912934 ) Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes ( 21829393 ) Multiple sclerosis ( 21833088 31604244 ) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376 ) Rheumatoid arthritis ( 24390342 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 ) Selective IgA deficiency ( 27723758 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: FCRL1	None recorded
Interacting Genes		11 interacting genes: AGPAT4 CMTM5 IGFBP5 MS4A1 PTPN11 PTPN6 SLC2A5 SLC30A3 STATH SYK ZAP70	30 interacting genes: AQP6 C16orf92 DERL3 ERGIC3 FAM209A FAM210B FCRL3 FKBP7 GET3 GPR152 GPR42 KCNJ6 LEUTX MRM1 MTIF3 OPRPN OVGP1 REEP4 SAR1A SGPL1 SLC10A1 SLC10A6 SLC35H1 SLC39A2 SLC61A1 SPNS3 TFAM TLCD4 TMEM80 TMX2
Entrez ID		115352	6779
HPRD ID		07352	01696
Ensembl ID		ENSG00000160856	ENSG00000126549
Uniprot IDs		Q96P31	P02808
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Phosphotyrosine Residue Binding Neutrophil Activation Involved In Immune Response Leukocyte Activation Neutrophil Activation Beta Selection Cell Activation Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Mediated By Integrin B Cell Activation Lymphocyte Activation Negative Regulation Of Neutrophil Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Proliferation Regulation Of Neutrophil Activation Positive Regulation Of T Cell Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Leukocyte Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway T Cell Receptor Complex Myeloid Leukocyte Activation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Platelet Formation Megakaryocyte Development Positive Regulation Of Alpha-beta T Cell Proliferation Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Regulation Of Lipopolysaccharide-mediated Signaling Pathway T Cell Selection Regulation Of Tumor Necrosis Factor Production Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Developmental Process Regulation Of B Cell Differentiation Positive Regulation Of Cell Adhesion Regulation Of Immune Response Regulation Of Cell Differentiation Regulation Of Cell-cell Adhesion	Bile Acid:sodium Symporter Activity