VASN and TGFB3

Number of citations of the paper that reports this interaction (PMID 15247411)
14

Data Source:
HPRD (in vitro, in vivo)

		VASN	TGFB3
Gene Name		vasorin	transforming growth factor, beta 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Mitochondrion Lysosomal Membrane Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface T-tubule Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body
	Molecular Function	Transforming Growth Factor Beta Binding	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Protein Heterodimerization Activity Transforming Growth Factor Beta Binding
	Biological Process	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Hypoxia Cellular Response To Redox State	Activation Of MAPK Activity Response To Hypoxia In Utero Embryonic Development Platelet Degranulation Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Salivary Gland Morphogenesis Female Pregnancy Aging Blood Coagulation Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Cell Growth Platelet Activation Extracellular Matrix Organization Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Response To Laminar Fluid Shear Stress Regulation Of Cell Proliferation Odontogenesis Uterine Wall Breakdown Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Ossification Involved In Bone Remodeling Cell-cell Junction Organization Positive Regulation Of DNA Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Digestive Tract Development Embryonic Neurocranium Morphogenesis Inner Ear Development Positive Regulation Of Protein Secretion Positive Regulation Of Filopodium Assembly Positive Regulation Of Cell Division Palate Development Face Morphogenesis Frontal Suture Morphogenesis Positive Regulation Of SMAD Protein Import Into Nucleus SMAD Protein Signal Transduction Detection Of Hypoxia
Pathways			Molecules associated with elastic fibres Elastic fibre formation Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: RNF31 TGFB1 TGFB2 TGFB3	13 interactors: ACVRL1 CCL20 CHMP2A CTGF ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN
Entrez ID		114990	7043
HPRD ID		10587	01829
Ensembl ID		ENSG00000168140
Uniprot IDs		Q6EMK4	A5YM40 B3KVH9 P10600
PDB IDs			1KTZ 1TGJ 1TGK 2PJY 3EO1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macrophage Cytokine Production SMAD Protein Import Into Nucleus Positive Regulation Of Epithelial To Mesenchymal Transition Face Morphogenesis Uterine Wall Breakdown Head Morphogenesis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Salivary Gland Morphogenesis Salivary Gland Development Response To Progesterone Face Development Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Exocrine System Development Body Morphogenesis Platelet Degranulation Ossification Involved In Bone Remodeling Regulation Of Cytokine Production Involved In Immune Response Frontal Suture Morphogenesis Positive Regulation Of Ossification Tissue Remodeling Protein Import Into Nucleus Nuclear Import Positive Regulation Of Cell Division Negative Regulation Of Immune Response Digestive Tract Development Transforming Growth Factor Beta Receptor Signaling Pathway Cell Growth Digestive System Development Protein Import Gland Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Intracellular Signal Transduction Cranial Suture Morphogenesis Protein Localization To Nucleus Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Immune Response Response To Transforming Growth Factor Beta Platelet Activation Positive Regulation Of Protein Secretion Regulation Of Ossification Regulation Of SMAD Protein Import Into Nucleus Craniofacial Suture Morphogenesis Response To Laminar Fluid Shear Stress Negative Regulation Of Cytokine Production Cell-cell Junction Organization	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cartilage Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Blood Vessel Development Vasculature Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Angiogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Component Movement Response To Wounding Tube Development Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Chondrocyte Differentiation Blood Vessel Morphogenesis Positive Regulation Of Protein Metabolic Process Cell Migration Response To Lipid Positive Regulation Of Phosphorylation Cardiovascular System Development Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Cell Proliferation Skeletal System Morphogenesis Skeletal System Development Extracellular Matrix Constituent Secretion Regulation Of Epithelial Cell Proliferation Organ Morphogenesis Regulation Of Cell Migration Regulation Of Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Wound Healing Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation
Tagcloud ?		accordingly addressed analog c6 cmed cmef consisting decompression degenerative disk diskectomy duratomy excel foraminal foraminotomy herniation hospitalization microendoscopic microsoft minimally modern ndi neck office operative spine stay stenosis vasa	alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfa thra1 transforming transmission trios utilizing
Tagcloud (Difference) ?		accordingly addressed analog c6 cmed cmef consisting decompression degenerative disk diskectomy duratomy excel foraminal foraminotomy herniation hospitalization microendoscopic microsoft minimally modern ndi neck office operative spine stay stenosis vasa	alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfa thra1 transforming transmission trios utilizing
Tagcloud (Intersection) ?