VASN and LCE3C

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		VASN	LCE3C
Description		vasorin	late cornified envelope 3C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Lysosomal Membrane Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Protein Binding Signaling Receptor Activity Cadherin Binding Transforming Growth Factor Beta Binding	Protein Binding
	Biological Process	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Hypoxia Cellular Response To Redox State	Epidermis Development Keratinization Killing Of Cells Of Another Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways			Formation of the cornified envelope
Drugs
Diseases
GWAS		A body shape index ( 34021172) Erectile dysfunction ( 30583798) Hip circumference adjusted for BMI ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		66 interacting genes: ADAMTSL4 AQP3 CFTR CIB4 CYSRT1 GRN GUCD1 HOXA1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-4 KRTAP5-6 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE4A LCE5A LNX1 MDFI MEOX2 MTUS2 NBPF19 NOTCH2NLA NR4A3 RGS17 RGS19 RGS20 RNF31 SMCP SSC4D TGFB1 TGFB2 TGFB3 TGM1 TRIP6 VWC2	66 interacting genes: ADAMTSL4 ALPP CHIC2 CYP21A2 CYSRT1 EFEMP2 GRN HOXA1 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1F LCE2B LCE2D LCE4A LCE5A MDFI NBPF19 NOTCH2NLA NUFIP2 PCSK5 PLSCR1 RGS17 RGS20 SPRY1 SPRY2 TRIM42 TSPAN4 VASN ZNF655
Entrez ID		114990	353144
HPRD ID		10587	17262
Ensembl ID		ENSG00000168140	ENSG00000244057
Uniprot IDs		Q6EMK4	Q5T5A8
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Type III Transforming Growth Factor Beta Receptor Binding Hair Cycle Identical Protein Binding Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Negative Regulation Of Macrophage Cytokine Production Uterine Wall Breakdown Protein Binding Transforming Growth Factor Beta Receptor Binding Odontogenesis Gland Morphogenesis Face Morphogenesis Regulation Of Enamel Mineralization Response To Progesterone Negative Regulation Of Cytokine Production Involved In Immune Response Interstitial Matrix Regulation Of Macrophage Cytokine Production Positive Regulation Of SMAD Protein Signal Transduction Structural Molecule Activity Type I Transforming Growth Factor Beta Receptor Binding	Intermediate Filament Keratin Filament Epidermis Development Keratinization Hair Cycle Cytosol Tissue Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Identical Protein Binding Bud Elongation Involved In Lung Branching Regulation Of Lens Fiber Cell Differentiation Protein Binding Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neurotrophin TRK Receptor Signaling Pathway
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