FBXO32 and EIF3A

Number of citations of the paper that reports this interaction (PMID 18354498)
48

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FBXO32	EIF3A
Gene Name		F-box protein 32	eukaryotic translation initiation factor 3, subunit A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Z Disc	Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Protein Binding	Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Cellular Response To Dexamethasone Stimulus	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways			Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CDC34 EIF3A EIF3F MLH1 SKP1 UBE2D3	16 interactors: BBS1 BBS4 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FBXO32 REL RNF139 TFIP11 UPF1 YWHAZ
Entrez ID		114907	8661
HPRD ID		05966	03618
Ensembl ID		ENSG00000156804	ENSG00000107581
Uniprot IDs		I6L984 Q0VAQ6 Q498Y9 Q969P5	F5H335 Q14152
PDB IDs
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Proteolysis Cellular Protein Catabolic Process Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Macromolecular Complex Assembly Catabolic Process Negative Regulation Of Mitotic Recombination G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Ribonucleoprotein Complex Assembly Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Cellular Protein Metabolic Process Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Cell Cycle Process DNA Metabolic Process Positive Regulation Of Inclusion Body Assembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of CAMP-mediated Signaling Regulation Of Translation Spindle Midzone Assembly Mature Ribosome Assembly Ribosomal Subunit Export From Nucleus Cytoplasmic Translational Initiation Ribonucleoprotein Complex Biogenesis Establishment Of Organelle Localization Resolution Of Meiotic Recombination Intermediates Histone H2A Monoubiquitination Cell Cycle Protein Metabolic Process Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Histone H2A Ubiquitination Cytoplasmic Translation Cellular Protein Modification Process	Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Translational Initiation Formation Of Translation Preinitiation Complex Translation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Gene Expression Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Cellular Component Assembly Ribonucleoprotein Complex Biogenesis Regulation Of Metabolic Process Nonmotile Primary Cilium Assembly Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Photoreceptor Cell Maintenance RNA Catabolic Process Cellular Metabolic Process MRNA Metabolic Process Cellular Response To Hormone Stimulus Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Macromolecular Complex Assembly Cellular Protein Metabolic Process Cerebellar Molecular Layer Development Spliceosomal Complex Disassembly Retina Homeostasis Response To Cytokine MRNA 3'-end Processing Vestibular Nucleus Development Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Metabolic Process Positive Regulation Of Cilium Assembly Cerebellum Maturation Sensory Processing Musculoskeletal Movement, Spinal Reflex Action Regulation Of Cellular Process RNA 3'-end Processing MRNA Processing Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Golgi Reassembly Gamma-aminobutyric Acid Secretion Response To Hormone Cytokine-mediated Signaling Pathway Aromatic Compound Catabolic Process
Tagcloud ?		ameliorated aquafeeds catabolic daidzein determines equol extend fishmeal genistein glycitein greatest ici legumes mitogenic mum mykiss myocyte nutrient oncorhynchus phytoestrogen phytoestrogens rainbow replacements salmonid soy soybeans trout turnover warrant	43s coerce compartmentalization compartmentalize compartmentalized concentrating evolve exited factories factory machinery margins nonstructural obstacle orthoreoviruses pic preinitiation ps6r reentered reovirus reoviruses ribopuromycylation sigmans spatiotemporally synthesizing tubulovesicular undertook vf visualize
Tagcloud (Difference) ?		ameliorated aquafeeds catabolic daidzein determines equol extend fishmeal genistein glycitein greatest ici legumes mitogenic mum mykiss myocyte nutrient oncorhynchus phytoestrogen phytoestrogens rainbow replacements salmonid soy soybeans trout turnover warrant	43s coerce compartmentalization compartmentalize compartmentalized concentrating evolve exited factories factory machinery margins nonstructural obstacle orthoreoviruses pic preinitiation ps6r reentered reovirus reoviruses ribopuromycylation sigmans spatiotemporally synthesizing tubulovesicular undertook vf visualize
Tagcloud (Intersection) ?