CYGB and ARHGAP8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYGB	ARHGAP8
Description		cytoglobin	Rho GTPase activating protein 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Nuclear Speck Neuron Projection Neuronal Cell Body	Cytoplasm Cytosol
	Molecular Function	Catalase Activity Peroxidase Activity Superoxide Dismutase Activity Oxygen Carrier Activity Iron Ion Binding Protein Binding Antioxidant Activity Oxidoreductase Activity Oxygen Binding Heme Binding Metal Ion Binding Fatty Acid Peroxidase Activity Carbon Monoxide Binding Nitrite Reductase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor	GTPase Activator Activity Protein Binding
	Biological Process	Response To Hypoxia Response To Oxidative Stress Negative Regulation Of Fibroblast Migration Oxygen Transport Fatty Acid Oxidation Removal Of Superoxide Radicals Negative Regulation Of Collagen Biosynthetic Process Nitric Oxide Metabolic Process Nitric Oxide Catabolic Process Negative Regulation Of Hepatic Stellate Cell Activation	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endocytic Recycling
Pathways		eNOS activation Intracellular oxygen transport	RHOA GTPase cycle
Drugs
Diseases
GWAS			Binge eating behaviour in bipolar disorder ( 29391396) Body mass index ( 28552196) Electroencephalographic traits in alcoholism ( 22554406) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Weight ( 28552196)
Interacting Genes		6 interacting genes: ARHGAP8 ATP13A2 DDI1 LRATD1 MZT1 PRR5-ARHGAP8	7 interacting genes: BNIP2 CFTR CTTN CYGB RHOA SH3GL1 ZMYND12
Entrez ID		114757	23779
HPRD ID		06479	06448
Ensembl ID		ENSG00000161544	ENSG00000241484
Uniprot IDs		Q8WWM9	P85298 Q6PJW1
PDB IDs		1UMO 1URV 1URY 1UT0 1UX9 1V5H 2DC3 3AG0 4B3W
Enriched GO Terms of Interacting Partners?		WW Domain Binding Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Microtubule Nucleation By Interphase Microtubule Organizing Center	Regulation Of Smooth Muscle Contraction Aortic Valve Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Neuron Differentiation Odontogenesis Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Muscle Contraction Skeletal Muscle Satellite Cell Migration Cell Projection Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Podosome Negative Regulation Of Hepatic Stellate Cell Activation Nitric Oxide Catabolic Process Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor Beta Selection Glutamatergic Synapse Positive Regulation Of Monoatomic Anion Transport Catalase Activity Carbon Monoxide Binding Bone Trabecula Morphogenesis Dendritic Spine Positive Regulation Of Enamel Mineralization Superoxide Dismutase Activity Nitrite Reductase Activity Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Cytoskeleton Organization Lamellipodium Endosome Cleavage Furrow Formation Regulation Of Neuron Differentiation Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Regulation Of Systemic Arterial Blood Pressure By Endothelin Cell Junction Regulation Of Muscle Contraction Positive Regulation Of Protein-containing Complex Assembly Roundabout Signaling Pathway Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Early Endosome Membrane Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport
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