CYGB and PRR5-ARHGAP8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYGB	PRR5-ARHGAP8
Description		cytoglobin	PRR5-ARHGAP8 readthrough
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Nuclear Speck Neuron Projection Neuronal Cell Body
	Molecular Function	Catalase Activity Peroxidase Activity Superoxide Dismutase Activity Oxygen Carrier Activity Iron Ion Binding Protein Binding Antioxidant Activity Oxidoreductase Activity Oxygen Binding Heme Binding Metal Ion Binding Fatty Acid Peroxidase Activity Carbon Monoxide Binding Nitrite Reductase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor
	Biological Process	Response To Hypoxia Response To Oxidative Stress Negative Regulation Of Fibroblast Migration Oxygen Transport Fatty Acid Oxidation Removal Of Superoxide Radicals Negative Regulation Of Collagen Biosynthetic Process Nitric Oxide Metabolic Process Nitric Oxide Catabolic Process Negative Regulation Of Hepatic Stellate Cell Activation
Pathways		eNOS activation Intracellular oxygen transport
Drugs
Diseases
GWAS			Body mass index ( 28552196) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Major depressive disorder ( 27777418) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Weight ( 28552196)
Interacting Genes		6 interacting genes: ARHGAP8 ATP13A2 DDI1 LRATD1 MZT1 PRR5-ARHGAP8	3 interacting genes: CYGB GRB2 ZMYND12
Entrez ID		114757	553158
HPRD ID		06479	18688
Ensembl ID		ENSG00000161544	ENSG00000248405
Uniprot IDs		Q8WWM9	B1AHC3
PDB IDs		1UMO 1URV 1URY 1UT0 1UX9 1V5H 2DC3 3AG0 4B3W
Enriched GO Terms of Interacting Partners?		WW Domain Binding Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Microtubule Nucleation By Interphase Microtubule Organizing Center	Guanyl-nucleotide Exchange Factor Adaptor Activity Grb2-EGFR Complex Negative Regulation Of Hepatic Stellate Cell Activation Nitric Oxide Catabolic Process Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor Catalase Activity Carbon Monoxide Binding Superoxide Dismutase Activity Nitrite Reductase Activity Neurotrophin TRKA Receptor Binding Branching Involved In Labyrinthine Layer Morphogenesis Insulin Receptor Substrate Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Negative Regulation Of Collagen Biosynthetic Process Oxygen Carrier Activity Removal Of Superoxide Radicals Negative Regulation Of Fibroblast Migration Oxygen Transport Schwann Cell Development Epidermal Growth Factor Receptor Binding Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity COP9 Signalosome Insulin-like Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Cell Activation Sperm Axoneme Assembly Nitric Oxide Metabolic Process Peroxidase Activity Antioxidant Activity Reactive Nitrogen Species Metabolic Process Oxygen Binding Endodermal Cell Differentiation Vesicle Membrane
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