CHRNE and CHRNA1

Number of citations of the paper that reports this interaction (PMID 1712080)
12

Data Source:
HPRD (in vitro)

		CHRNE	CHRNA1
Gene Name		cholinergic receptor, nicotinic, epsilon (muscle)	cholinergic receptor, nicotinic, alpha 1 (muscle)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Cell Junction Postsynaptic Membrane	Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Cell Junction Neuromuscular Junction Postsynaptic Membrane
	Molecular Function	Acetylcholine-activated Cation-selective Channel Activity Cation Transmembrane Transporter Activity Acetylcholine Receptor Activity	Acetylcholine-activated Cation-selective Channel Activity Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine Binding
	Biological Process	Transport Muscle Contraction Signal Transduction Synaptic Transmission Synaptic Transmission, Cholinergic Regulation Of Membrane Potential Cation Transmembrane Transport	Skeletal Muscle Contraction Transport Signal Transduction Synaptic Transmission Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Ion Transmembrane Transport Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Musculoskeletal Movement Neuromuscular Process Neuron Cellular Homeostasis Cation Transmembrane Transport
Pathways		Acetylcholine Binding And Downstream Events Postsynaptic nicotinic acetylcholine receptors Activation of Nicotinic Acetylcholine Receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly sodium permeable acetylcholine nicotinic receptors Transmission across Chemical Synapses	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Activation of Nicotinic Acetylcholine Receptors Postsynaptic nicotinic acetylcholine receptors Presynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Highly calcium permeable nicotinic acetylcholine receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: CHRNA1	4 interactors: CHRND CHRNE CHRNG ITGA7
Entrez ID		1145	1134
HPRD ID		00008	00007
Ensembl ID		ENSG00000108556	ENSG00000138435
Uniprot IDs		Q04844	P02708 Q53SH4
PDB IDs		2DF9	1Y5P 1Y5T 1Y6C
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Tissue Growth Neuron Cellular Homeostasis Neuromuscular Synaptic Transmission Muscle Cell Cellular Homeostasis Skeletal Muscle Contraction Neuronal Action Potential Musculoskeletal Movement Neuromuscular Junction Development Transmission Of Nerve Impulse Striated Muscle Contraction Action Potential Neuromuscular Process Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Synapse Organization Muscle Contraction Muscle System Process Regulation Of Membrane Potential Muscle Organ Development Developmental Growth Striated Muscle Tissue Development Muscle Tissue Development Growth Muscle Structure Development	Muscle Contraction Muscle System Process Regulation Of Membrane Potential Synaptic Transmission Skeletal Muscle Tissue Development Cell-cell Signaling Skeletal Muscle Organ Development Cation Transmembrane Transport Skeletal Muscle Tissue Growth Cation Transport Ion Transmembrane Transport Muscle Organ Development Striated Muscle Tissue Development Muscle Tissue Development Transmembrane Transport Ion Transport Synaptic Transmission, Cholinergic Signal Transduction Muscle Structure Development Signaling Cell Communication Heterotypic Cell-cell Adhesion Skeletal Muscle Contraction Cellular Response To Stimulus Endodermal Cell Differentiation Musculoskeletal Movement Endoderm Formation Striated Muscle Contraction Response To Stimulus Endoderm Development Integrin-mediated Signaling Pathway Neuromuscular Process Formation Of Primary Germ Layer Regulation Of Cell Shape Cell-matrix Adhesion Tissue Development
Tagcloud ?		16x10 associations comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 plcg2 prlr rank resampling rps6kb2 tln1 validate warranted wasl	ags aire autoimmune autoimmunity copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
Tagcloud (Difference) ?		16x10 associations comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 plcg2 prlr rank resampling rps6kb2 tln1 validate warranted wasl	ags aire autoimmune autoimmunity copies ds dysregulation euploid fundamental gad1 graves hypothyroidism intrathymic klk3 owing pge plp1 predisposition promiscuous restricted sag strikingly thymus thymuses thyroglobulin thyroiditis tolerance trisomy typically
Tagcloud (Intersection) ?