CHRNA7 and AQR

		CHRNA7	AQR
Description		cholinergic receptor nicotinic alpha 7 subunit	aquarius intron-binding spliceosomal factor
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Acetylcholine-gated Channel Complex Membrane Dendrite Cation Channel Complex Neuron Projection Plasma Membrane Raft Synapse Postsynaptic Membrane Postsynapse Neurotransmitter Receptor Complex	Nucleus Nucleoplasm Spliceosomal Complex Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Acetylcholine Receptor Activity Toxic Substance Binding Chloride Channel Regulator Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Protein Homodimerization Activity	Nucleotide Binding RNA Binding RNA Helicase Activity Single-stranded RNA Binding MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity
	Biological Process	Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Signal Transduction Canonical NF-kappaB Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Learning Or Memory Memory Short-term Memory Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor Production Monoatomic Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Synapse Organization Cognition Sensory Processing Positive Regulation Of Protein Metabolic Process Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Acetylcholine Receptor Signaling Pathway Dendritic Spine Organization Modulation Of Excitatory Postsynaptic Potential Dendrite Arborization Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Response To Amyloid-beta Response To Acetylcholine Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of Amyloid Fibril Formation Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs		Choline Nicotine Succinylcholine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Cisatracurium Thiopental Mecamylamine Galantamine Primidone Methylphenobarbital Ethanol Amantadine Phenobarbital Tubocurarine Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Acetylcholine Lobeline GTS-21 RPI-78M Epibatidine Cytisine Cannabidiol Encenicline Choline salicylate Medical Cannabis Nabiximols
Diseases
GWAS		Hepatocyte growth factor levels ( 25998175)
Interacting Genes		5 interacting genes: ADCY6 APP ATXN1 CFTR PIK3R1	40 interacting genes: MIR1-1 MIR106A MIR106B MIR107 MIR128-2 MIR145 MIR15B MIR199A2 MIR19B1 MIR19B2 MIR200B MIR200C MIR205 MIR206 MIR20B MIR214 MIR221 MIR222 MIR25 MIR29A MIR31 MIR34A MIR34B MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7G MIRLET7I PQBP1 RBM22 RBM4 WDR77
Entrez ID		1139	9716
HPRD ID		00339	12468
Ensembl ID		ENSG00000175344	ENSG00000021776
Uniprot IDs		P36544	O60306
PDB IDs		2MAW 5AFH 5AFJ 5AFK 5AFL 5AFM 5AFN 7EKI 7EKP 7EKT 7KOO 7KOQ 7KOX 7RPM 8C9X 8CAU 8CE4 8CI1 8CI2 8F4V 8P1H 8UT1 8UTB 8UZJ 8V80 8V82 8V86 8V88 8V89 8V8A 8V8C 8V8D	4PJ3 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7ABI 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Visual Behavior Visual Learning Response To Light Stimulus Associative Learning Cellular Response To Forskolin Response To Radiation Response To Forskolin Response To Catecholamine Cellular Response To Catecholamine Stimulus Learning Insulin Receptor Binding Multicellular Organismal-level Water Homeostasis Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Transport Positive Regulation Of Response To Endoplasmic Reticulum Stress Learning Or Memory Cellular Response To Oxygen-containing Compound Chemical Homeostasis Cognition Positive Regulation Of Establishment Of Protein Localization Cellular Response To CAMP Multicellular Organismal-level Chemical Homeostasis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Adult Locomotory Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Membrane Potential Regulation Of Protein Transport Positive Regulation Of Protein Localization Response To CAMP Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Myeloid Cell Differentiation Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Positive Regulation Of Tumor Necrosis Factor Production Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anion Channel Activity Homeostatic Process PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing RISC Complex MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Metabolic Process Negative Regulation Of Translation Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Metabolic Process Regulation Of MRNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Cytokine Production Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Multicellular Organismal Development Negative Regulation Of Developmental Process Regulation Of Muscle Cell Differentiation Negative Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Signal Transduction
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