CHRNA7 and ADCY6

Number of citations of the paper that reports this interaction (PubMedID 12748066)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CHRNA7	ADCY6
Description		cholinergic receptor nicotinic alpha 7 subunit	adenylate cyclase 6
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Acetylcholine-gated Channel Complex Membrane Dendrite Cation Channel Complex Neuron Projection Plasma Membrane Raft Synapse Postsynaptic Membrane Postsynapse Neurotransmitter Receptor Complex	Plasma Membrane Cilium Membrane Stereocilium Cell Projection
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Acetylcholine Receptor Activity Toxic Substance Binding Chloride Channel Regulator Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Protein Homodimerization Activity	Nucleotide Binding Adenylate Cyclase Activity Protein Kinase C Binding Protein Binding ATP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Protein Kinase Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Signal Transduction Canonical NF-kappaB Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Learning Or Memory Memory Short-term Memory Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor Production Monoatomic Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Synapse Organization Cognition Sensory Processing Positive Regulation Of Protein Metabolic Process Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Acetylcholine Receptor Signaling Pathway Dendritic Spine Organization Modulation Of Excitatory Postsynaptic Potential Dendrite Arborization Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Response To Amyloid-beta Response To Acetylcholine Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of Amyloid Fibril Formation Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential	Renal Water Homeostasis CAMP Biosynthetic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Negative Regulation Of Neuron Projection Development Intracellular Signal Transduction Negative Regulation Of Urine Volume Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus Blood Vessel Diameter Maintenance Cellular Response To Vasopressin Cellular Response To Forskolin
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Choline Nicotine Succinylcholine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Cisatracurium Thiopental Mecamylamine Galantamine Primidone Methylphenobarbital Ethanol Amantadine Phenobarbital Tubocurarine Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Acetylcholine Lobeline GTS-21 RPI-78M Epibatidine Cytisine Cannabidiol Encenicline Choline salicylate Medical Cannabis Nabiximols	Colforsin
Diseases
GWAS		Hepatocyte growth factor levels ( 25998175)	Clozapine-induced agranulocytosis ( 25187353) Height ( 28552196)
Interacting Genes		5 interacting genes: ADCY6 APP ATXN1 CFTR PIK3R1	4 interacting genes: ATXN1 CHRNA7 GNAS RAF1
Entrez ID		1139	112
HPRD ID		00339	02621
Ensembl ID		ENSG00000175344	ENSG00000174233
Uniprot IDs		P36544	O43306
PDB IDs		2MAW 5AFH 5AFJ 5AFK 5AFL 5AFM 5AFN 7EKI 7EKP 7EKT 7KOO 7KOQ 7KOX 7RPM 8C9X 8CAU 8CE4 8CI1 8CI2 8F4V 8P1H 8UT1 8UTB 8UZJ 8V80 8V82 8V86 8V88 8V89 8V8A 8V8C 8V8D
Enriched GO Terms of Interacting Partners?		Visual Behavior Visual Learning Response To Light Stimulus Associative Learning Cellular Response To Forskolin Response To Radiation Response To Forskolin Response To Catecholamine Cellular Response To Catecholamine Stimulus Learning Insulin Receptor Binding Multicellular Organismal-level Water Homeostasis Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Transport Positive Regulation Of Response To Endoplasmic Reticulum Stress Learning Or Memory Cellular Response To Oxygen-containing Compound Chemical Homeostasis Cognition Positive Regulation Of Establishment Of Protein Localization Cellular Response To CAMP Multicellular Organismal-level Chemical Homeostasis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Adult Locomotory Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Membrane Potential Regulation Of Protein Transport Positive Regulation Of Protein Localization Response To CAMP Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Myeloid Cell Differentiation Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Positive Regulation Of Tumor Necrosis Factor Production Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anion Channel Activity Homeostatic Process PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import	Adenylate Cyclase Activator Activity Cognition Insulin-like Growth Factor Receptor Signaling Pathway Excitatory Postsynaptic Potential Memory Regulation Of Postsynaptic Membrane Potential Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Regulation Of Biological Quality Nervous System Process Chemical Homeostasis Regulation Of Developmental Process Mu-type Opioid Receptor Binding Death-inducing Signaling Complex Assembly Synaptic Transmission Involved In Micturition Regulation Of Signal Transduction Sensory Processing Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity POZ Domain Binding Postsynapse Hair Follicle Placode Formation Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Acetylcholine Binding Learning Or Memory Positive Regulation Of Metabolic Process Regulation Of Cell Communication Dendrite Arborization Neurotransmitter Receptor Complex Short-term Memory Toxic Substance Binding Negative Regulation Of Cell Communication Homeostatic Process Chloride Channel Regulator Activity Regulation Of Signaling Response To Acetylcholine Negative Regulation Of Signaling Negative Regulation Of 3'-UTR-mediated MRNA Stabilization System Process D1 Dopamine Receptor Binding Cellular Response To Glucagon Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Beta-2 Adrenergic Receptor Binding Animal Organ Development Establishment Of Localization In Cell Serotonin Receptor Signaling Pathway Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Insulin Secretion Involved In Cellular Response To Glucose Stimulus
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