HENMT1 and INCA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HENMT1	INCA1
Description		HEN methyltransferase 1	inhibitor of CDK, cyclin A1 interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm P Granule	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity RNA Methyltransferase Activity Transferase Activity Metal Ion Binding Small RNA 2'-O-methyltransferase Activity	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	RNA Methylation SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Methylation PiRNA Processing	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway
Pathways		PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS			Intraocular pressure ( 29235454) Keratoconus ( 33649486) Obesity-related traits ( 23251661)
Interacting Genes		3 interacting genes: CCDC74B INCA1 TRAF2	236 interacting genes: ABI2 ACTMAP ACY3 AKAP8L ANKRD28 ARMC7 ASPSCR1 ATG5 ATP6V0D2 ATPAF2 BAG3 BANF2 BOLA3 BPIFA1 C10orf55 C1orf35 C1orf50 C1orf56 C22orf39 CABP5 CCBE1 CCDC57 CCDC78 CCNA1 CDA CDC23 CDK18 CDK2 CDK4 CDKN1A CDKN2B CDKN2D CEP72 CHCHD2 CHCHD5 CHRD CINP CKS1B CLIC3 CLK3 COL8A1 CPSF1 CSDC2 CSTF2 CTNNBIP1 CTTNBP2 CYSRT1 DAZAP2 DEF6 DMRT3 DMRTB1 DOK4 DPH7 DUSP13B EFEMP2 EMD EPHB6 EXOSC8 FAAP20 FAIM FEM1A FGF16 FHL2 FMR1 FRS3 GEM GEMIN2 GRB2 GRXCR1 GSTO2 GTF2H5 GTPBP3 GYS1 HAUS1 HCK HDAC4 HEMK1 HENMT1 HNRNPF HOMER3 HOXA1 HR HSD17B14 HYI IL36RN ILF2 KCTD7 KCTD9 KIAA1217 KIR2DL4 KLHL26 KLHL42 KRT33B KRT5 KRT75 KRTAP15-1 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP5-6 KRTAP6-2 KRTAP6-3 KRTAP9-3 LENG8 LGALS3 LHX3 LMNTD2 LMO2 LMO3 LSM3 LYPLA2 MAD2L2 MAGED4B MAGOHB MALSU1 MARF1 MARK1 MATN3 MBLAC1 METAP1 MPP1 MSRB1 MTMR9 NATD1 NCK2 NDUFAF3 NEDD9 NEIL2 NEK6 NFKBID NHSL2 NME7 NMRK1 NPAS2 NTAQ1 NUBP2 NUDT16L1 NUDT22 OR6B1 OSGIN1 PADI3 PATE1 PCSK5 PCYT2 PDP1 PEF1 PFDN5 PHF1 PLA2G10 PLSCR3 POLR1C POLR3C POP5 POU4F2 PRPH PSMB2 PSMB8 PTGER3 R3HDM2 RAB5C RALB RAMAC RBPMS RECK RFC3 RIPPLY3 RNF26 SAP18 SAXO4 SCNM1 SEC14L4 SHFL SLC67A1-AS SMG9 SMUG1 SNRPB SPAG8 SPG21 SPOUT1 SPRY1 STAMBPL1 STK16 STT3B SUOX TBC1D7 TCL1A TEAD4 TEKT4 TEX12 TFAP2A TFAP2D TFAP4 TFG THAP6 THRSP TIAL1 TPRX1 TRAPPC2 TRAPPC2B TRAPPC6A TRIB3 TRIM26 TRIM55 TRIM63 TRIM68 TRIP13 TRIP6 TSEN15 TSG101 TSSK3 TSTD2 TXNDC17 UBASH3B UBE2D4 UBE2Z UBTD2 UBXN2B UFM1 UFSP1 VEZF1 VGLL3 VPS26C VPS28 WWOX YIPF3 YOD1 ZDHHC24 ZFAND3 ZMYND12 ZMYND19 ZNF205-AS1 ZNF32 ZNF446 ZNF747 ZNF765 ZNRD2
Entrez ID		113802	388324
HPRD ID		08086	17150
Ensembl ID		ENSG00000162639	ENSG00000196388
Uniprot IDs		Q5T8I9	Q0VD86
PDB IDs		4XCX 5WY0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Signaling Pathway TORC2 Complex Disassembly TRAF2-GSTP1 Complex Regulation Of Protein Serine/threonine Kinase Activity TORC1 Complex Assembly CD40 Receptor Binding Regulation Of Protein Kinase Activity Sphingolipid Binding Regulation Of Kinase Activity IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex CD27 Signaling Pathway Thioesterase Binding CD40 Receptor Complex Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation CD40 Signaling Pathway Protein-containing Complex Binding Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Phosphorylation Apoptotic Signaling Pathway Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Interleukin-17-mediated Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of JUN Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Programmed Cell Death TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Cellular Response To Reactive Nitrogen Species Regulation Of Phosphorus Metabolic Process Response To Nitric Oxide Programmed Necrotic Cell Death Regulation Of Protein Modification Process Positive Regulation Of T Cell Cytokine Production Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Protein Serine/threonine Kinase Activity Cyclin Binding Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of MAP Kinase Activity Positive Regulation Of Interleukin-2 Production	Protein Binding Intermediate Filament Cytosol COPII Vesicle Coating Spindle Pole Centrosome Cytoplasm Nucleus Identical Protein Binding Cyclin A1-CDK2 Complex MRNA Processing Vesicle Coating Positive Regulation Of Ubiquitin-dependent Endocytosis
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