KLHDC7B and A1CF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLHDC7B	A1CF
Description		kelch domain containing 7B	APOBEC1 complementation factor
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Apolipoprotein B MRNA Editing Enzyme Complex MRNA Editing Complex
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Enzyme-substrate Adaptor Activity
	Biological Process		MRNA Processing Embryo Implantation MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression Cytidine To Uridine Editing MRNA Modification Low-density Lipoprotein Particle Clearance Protein Stabilization Chromosomal 5-methylcytosine DNA Demethylation Pathway Negative Regulation Of MRNA Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways			mRNA Editing: C to U Conversion Formation of the Editosome
Drugs
Diseases
GWAS		Age-related hearing impairment ( 34108613) Mean corpuscular hemoglobin ( 20139978) Monocyte count ( 32888494) Red blood cell count ( 29403010) Serum metabolite levels ( 33031748)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31451708 31152163 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) Gamma glutamyl transferase levels ( 33339817) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731) Narcolepsy with cataplexy ( 25986216) Serum uric acid levels ( 30993211) Total cholesterol levels ( 30275531) Triglyceride levels ( 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 31578528 31985003 23263486) Urate levels in lean individuals ( 25811787)
Interacting Genes		25 interacting genes: A1CF BHLHE40 CFTR DTX2 ESRP1 FNDC3B HNRNPUL1 LIMS3 LIMS4 MAPRE3 NFYC PATZ1 PHC2 POGZ QRICH1 RBPMS RBPMS2 RHOXF2 SMUG1 SPMIP9 TBX6 TLE5 TP53BP1 WWOX ZC3H10	26 interacting genes: ACTMAP APOBEC1 CAVIN2 CELF2 CYSRT1 DOK3 ECM1 EIF4G1 FHL2 FHL3 HSPB2 HSPB2-C11orf52 KHSRP KLHDC7B KRT31 KRT34 METTL27 OIP5 PLEKHG4 POGZ REL RIMBP3C SPMIP6 SYNCRIP TNPO2 TRAF1
Entrez ID		113730	29974
HPRD ID		14453	10627
Ensembl ID		ENSG00000130487	ENSG00000148584
Uniprot IDs		A0A3B3ISF6 Q96G42	B4E1E3 F8W9F8 Q9NQ94
PDB IDs			2CPD
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA Binding MRNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Single-strand Selective Uracil DNA N-glycosylase Activity Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Positive Regulation Of Metabolic Process	Chromosomal 5-methylcytosine DNA Demethylation Pathway MRNA Editing Complex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Modification Manchette
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