NACC1 and SENP2

Number of citations of the paper that reports this interaction (PubMedID 25891951)
45

Data Source:
BioGRID (enzymatic study)

		NACC1	SENP2
Description		nucleus accumbens associated 1	SUMO specific peptidase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cell Junction Nuclear Lumen	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Body PML Body Nuclear Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Histone Deacetylase Binding	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription	Proteolysis Heart Development Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of DNA Endoreduplication Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Regulation Of Macromolecule Metabolic Process Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			SUMO is proteolytically processed
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Diastolic blood pressure ( 27841878 28135244) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462 31152163) Height ( 28552196) Hip circumference ( 28552196) JT interval ( 29874175) PR interval ( 30046033 32439900) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 26969751 27841878)
Interacting Genes		20 interacting genes: BCOR C8orf33 CCNB1 EHHADH ELOA HDAC3 HDAC4 LGALS8 LSM3 PML POLR2L PRKCI PRPF18 PRPF3 SENP1 SENP2 TARDBP UBE2I UBTFL1 ZNF512B	40 interacting genes: ACSF2 AGTRAP APOC2 APOC4 APP AR ARL6IP1 ARMC12 AXIN1 CDCA5 CDK5RAP2 DAXX ERCC6 FUNDC1 FZR1 HCCS IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 OGT PML RANGAP1 RETREG3 RPRM SDR16C5 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TNFRSF10D TPD52 TRIM63
Entrez ID		112939	59343
HPRD ID		10692	07002
Ensembl ID		ENSG00000160877	ENSG00000163904
Uniprot IDs		Q96RE7	Q9HC62
PDB IDs		3GA1 4U2N 7BV9 8YZS	1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Nucleoplasm Regulation Of RNA Metabolic Process SUMO Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex SUMO-specific Endopeptidase Activity Nucleus DeSUMOylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Desumoylation Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Gene Expression RNA Metabolic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Transcription By RNA Polymerase I Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of Circadian Rhythm Negative Regulation Of Macromolecule Biosynthetic Process Maintenance Of Protein Location In Nucleus Macromolecule Deacylation Negative Regulation Of Metabolic Process Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process RNA Splicing Regulation Of Protein Stability Response To DDT Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Interleukin-1 Production Negative Regulation Of Translation In Response To Oxidative Stress Negative Regulation Of Catabolic Process Maintenance Of Protein Localization In Organelle Regulation Of Transcription By RNA Polymerase I SUMO Conjugating Enzyme Activity	Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Regulation Of Proteolysis Nuclear Membrane Protein Modification By Small Protein Conjugation Protein Localization To Nucleus PML Body Protein Tag Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Import Into Nucleus Nuclear Envelope Import Into Nucleus Very-low-density Lipoprotein Particle Chromatin Organization Post-translational Protein Modification Endoplasmic Reticulum Tubular Network Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nuclear Localization Sequence Binding High-density Lipoprotein Particle Regulation Of Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate-density Lipoprotein Particle Nucleus Organization Protein Binding DNA Damage Response Positive Regulation Of Protein Metabolic Process Protein Localization To Organelle Regulation Of Proteasomal Protein Catabolic Process PML Body Organization Chromatin Remodeling Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Regulation Of Protein Localization Molecular Condensate Scaffold Activity Programmed Cell Death Protein Modification Process NLS-dependent Protein Nuclear Import Complex Meiotic Nuclear Membrane Microtubule Tethering Complex
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