TP53RK and SYNE1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		TP53RK	SYNE1
Description		TP53 regulating kinase	spectrin repeat containing nuclear envelope protein 1
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GO Annotations	Cellular Component	EKC/KEOPS Complex Nucleus Nucleoplasm Cytoplasm Cytosol	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane
	Molecular Function	Nucleotide Binding P53 Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Protein Serine Kinase Activity	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	Protein Phosphorylation TRNA Processing TRNA Threonylcarbamoyladenosine Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator	Nucleus Organization Golgi Organization Spermatogenesis Cell Differentiation Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane
Pathways		tRNA modification in the nucleus and cytosol Regulation of TP53 Activity through Phosphorylation	Meiotic synapsis
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Emery-Dreifuss muscular dystrophy
GWAS		Dimensional psychopathology (Arousal) ( 29496196) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 20351715 21738484 21926972 34002096 28072414 28115744 31043756) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 30194396 31249589 31649266)
Interacting Genes		11 interacting genes: CALCOCO2 CHN2 CLK1 DCTN1 GORASP2 LRRC2 MDM2 MTUS2 SYNE1 TP53 TPRKB	28 interacting genes: ACTC1 APC BDKRB2 BTG3 CAPN1 CDC42 CDC5L CEP63 DISC1 DSCAM DSCR9 DTNBP1 ECPAS EMD ITSN1 LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 PCNT SH3BP5 TNIK TP53RK USP21 USP7 XIAP
Entrez ID		112858	23345
HPRD ID		12276	09762
Ensembl ID		ENSG00000172315	ENSG00000131018
Uniprot IDs		Q96S44	A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91
PDB IDs		6WQX 7SZA 7SZB 7SZC 7SZD	4DXR 6R15 6XF2
Enriched GO Terms of Interacting Partners?		Response To Actinomycin D Cellular Response To Actinomycin D Cellular Response To UV-C Cellular Response To Antibiotic Response To UV-C Cellular Response To Gamma Radiation Disordered Domain Specific Binding Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Formaldehyde Cellular Response To Vitamin B1 Response To Gamma Radiation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Transcription Repressor Complex Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development Intercellular Bridge Cytoskeleton Cardiac Septum Morphogenesis Response To Vitamin B1 P53 Binding Enzyme Binding Cellular Response To UV Response To Water-immersion Restraint Stress Cellular Response To Ionizing Radiation Signal Transduction By P53 Class Mediator Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Nuclear Matrix Anchoring At Nuclear Membrane NEDD8 Ligase Activity Cellular Response To Light Stimulus Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive Regulation Of Thymocyte Apoptotic Process T Cell Proliferation Involved In Immune Response PML Body Golgi Organization Nuclear Matrix Organization Regulation Of Signal Transduction By P53 Class Mediator	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Cytotoxicity Signal Transduction Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Postsynapse Organization Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Cytoskeleton Organization Regulation Of Synapse Organization Microtubule Organizing Center Molecular Adaptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Radial Glia-guided Pyramidal Neuron Migration Antigen Processing And Presentation Centrosome Regulation Of T Cell Mediated Immunity Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell Cycle Natural Killer Cell Mediated Immunity Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leading Edge Membrane Positive Regulation Of Lymphocyte Mediated Immunity Glutamatergic Synapse Regulation Of Dendritic Spine Development Positive Regulation Of Adaptive Immune Response Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cytoskeleton Neuron Projection Morphogenesis Cytosol Wnt Signaling Pathway Positive Regulation Of Pseudopodium Assembly Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Leukocyte Mediated Cytotoxicity Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Wnt Signaling Pathway Cerebral Cortex Radially Oriented Cell Migration Regulation Of Protein Localization
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