TP53RK and TPRKB

Number of citations of the paper that reports this interaction (PMID 23455922)
9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		TP53RK	TPRKB
Gene Name		TP53 regulating kinase	TP53RK binding protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	EKC/KEOPS Complex Nucleus Cytosol Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Hydrolase Activity	Protein Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation TRNA Processing Threonylcarbamoyladenosine Metabolic Process	TRNA Processing
Pathways
Drugs
Diseases
GWAS			Creatinine levels ( 20383145) Metabolite levels ( 21931564)
Protein-Protein Interactions		4 interactors: CALCOCO2 MTUS2 TP53 TPRKB	2 interactors: TP53RK TRIM27
Entrez ID		112858	51002
HPRD ID		12276	12277
Ensembl ID		ENSG00000172315	ENSG00000144034
Uniprot IDs		Q5JZ02 Q96S44	Q9Y3C4
PDB IDs			3ENP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Negative Regulation Of Helicase Activity Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Mitochondrial DNA Repair Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence ER Overload Response Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Positive Regulation Of T Cell Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Strand Renaturation Viral Process DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic Cell Cycle Arrest Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Thymocyte Apoptotic Process Replicative Senescence Positive Regulation Of Mitochondrial Membrane Permeability Determination Of Adult Lifespan Positive Regulation Of Lymphocyte Apoptotic Process Circadian Behavior Mitochondrial DNA Metabolic Process Positive Regulation Of Histone Deacetylation Rhythmic Behavior Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Protein Oligomerization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process RRNA Transcription T Cell Lineage Commitment Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Protein Deacetylation Cellular Response To Glucose Starvation Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Neuroblast Proliferation Photoperiodism Entrainment Of Circadian Clock Protein Import Into Nucleus, Translocation Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitochondrial Genome Maintenance Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Necroptotic Process	Negative Regulation Of Interleukin-2 Secretion Threonylcarbamoyladenosine Metabolic Process Negative Regulation Of Calcium Ion Import Interferon-gamma Secretion Adenosine Metabolic Process Negative Regulation Of Viral Release From Host Cell Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Regulation Of Calcium Ion Import Protein K63-linked Ubiquitination Cytokine Secretion Protein Trimerization Negative Regulation Of Cytokine Secretion Negative Regulation Of Adaptive Immune Response Protein Phosphorylation Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Calcium Ion Transport Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Actin Nucleation Retrograde Transport, Endosome To Golgi Regulation Of Viral Transcription Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Viral Process Phosphorylation
Tagcloud ?			atxn2 bid ccnf cdkn1a cntn4 dcp1b dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia tia1 tial1 translocate upregulations wdfy1
Tagcloud (Difference) ?			atxn2 bid ccnf cdkn1a cntn4 dcp1b dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia tia1 tial1 translocate upregulations wdfy1
Tagcloud (Intersection) ?