TP53RK and TPRKB

Number of citations of the paper that reports this interaction (PubMedID 32707033)
104

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		TP53RK	TPRKB
Description		TP53 regulating kinase	TP53RK binding protein
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GO Annotations	Cellular Component	EKC/KEOPS Complex Nucleus Nucleoplasm Cytoplasm Cytosol	EKC/KEOPS Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding P53 Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Protein Serine Kinase Activity	Protein Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation TRNA Processing TRNA Threonylcarbamoyladenosine Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator	TRNA Threonylcarbamoyladenosine Modification TRNA Processing
Pathways		tRNA modification in the nucleus and cytosol Regulation of TP53 Activity through Phosphorylation	tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Dimensional psychopathology (Arousal) ( 29496196) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood metabolite levels ( 26401656) Creatinine levels ( 20383145) Estimated glomerular filtration rate in diabetes ( 31451708) Metabolite levels ( 21931564) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944 33031748)
Interacting Genes		11 interacting genes: CALCOCO2 CHN2 CLK1 DCTN1 GORASP2 LRRC2 MDM2 MTUS2 SYNE1 TP53 TPRKB	2 interacting genes: TP53RK TRIM27
Entrez ID		112858	51002
HPRD ID		12276	12277
Ensembl ID		ENSG00000172315	ENSG00000144034
Uniprot IDs		Q96S44	Q9Y3C4
PDB IDs		6WQX 7SZA 7SZB 7SZC 7SZD	3ENP 6WQX 7SZA 7SZB 7SZC 7SZD
Enriched GO Terms of Interacting Partners?		Response To Actinomycin D Cellular Response To Actinomycin D Cellular Response To UV-C Cellular Response To Antibiotic Response To UV-C Cellular Response To Gamma Radiation Disordered Domain Specific Binding Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Formaldehyde Cellular Response To Vitamin B1 Response To Gamma Radiation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Transcription Repressor Complex Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development Intercellular Bridge Cytoskeleton Cardiac Septum Morphogenesis Response To Vitamin B1 P53 Binding Enzyme Binding Cellular Response To UV Response To Water-immersion Restraint Stress Cellular Response To Ionizing Radiation Signal Transduction By P53 Class Mediator Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Nuclear Matrix Anchoring At Nuclear Membrane NEDD8 Ligase Activity Cellular Response To Light Stimulus Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive Regulation Of Thymocyte Apoptotic Process T Cell Proliferation Involved In Immune Response PML Body Golgi Organization Nuclear Matrix Organization Regulation Of Signal Transduction By P53 Class Mediator	Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription SUMO Transferase Activity Arp2/3 Complex-mediated Actin Nucleation Retromer Complex Phosphatidylinositol 3-kinase Inhibitor Activity Positive Regulation Of Actin Nucleation TRNA Threonylcarbamoyladenosine Metabolic Process EKC/KEOPS Complex Actin Nucleation
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