NRM and HDAC11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NRM	HDAC11
Description		nurim	histone deacetylase 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Membrane Nuclear Membrane	Histone Deacetylase Complex Nucleus Plasma Membrane
	Molecular Function	Protein Binding	Histone Deacetylase Activity Protein Binding Hydrolase Activity DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism
	Biological Process		Chromatin Organization Epigenetic Regulation Of Gene Expression
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway
Drugs			Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Alcohol dependence symptom count ( 27151647) Autism spectrum disorder or schizophrenia ( 28540026) Height ( 31217584) Itch intensity from mosquito bite ( 28199695) Number of sexual partners ( 30643258)	Body mass index ( 26426971) Height ( 20881960) Hip circumference adjusted for BMI ( 25673412 34021172) Ulcerative colitis ( 26278503) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		51 interacting genes: AGR3 ANK1 AQP6 ARL13B ATP6V0B BIK CLRN1 CNR2 CPLX4 CREB3L1 CYB5R3 CYBC1 ERGIC3 ERP29 FAM209A FCER1G FFAR2 FRMD3 GOLT1A GORAB GPR151 GPR42 GPX8 HDAC11 HHLA2 HSD17B13 KIR2DL3 MFF MGST3 MRM1 OPN1LW PARP15 PEX12 RETREG3 RHBDD2 RMDN3 RNASEH1 SAR1A SCN3B SLC10A2 SLC10A6 SLC18A1 SLC30A2 SLC35H1 SPAG4 SSMEM1 STX1A SUN2 TMEM52B TMX2 TRIM59	7 interacting genes: CDC25A CDKN1A HDAC6 MAPK6 NELFCD NRM PHYHIP
Entrez ID		11270	79885
HPRD ID		10120	09146
Ensembl ID		ENSG00000137404	ENSG00000163517
Uniprot IDs		A0A1U9X845 B3KQU6 Q8IXM6	B5MCQ6 Q96DB2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Endoplasmic Reticulum Bile Acid:sodium Symporter Activity	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Replication PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Septin Cytoskeleton Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Tubulin Deacetylase Activity Protein Kinase Binding Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Developmental Growth Tubulin Deacetylation Positive Regulation Of Response To Oxidative Stress Regulation Of Cholangiocyte Proliferation Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Replication Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Oligomerization NELF Complex Regulation Of Reactive Oxygen Species Metabolic Process Mitotic Cell Cycle Phase Transition Type 2 Mitophagy ATPase Inhibitor Activity Erythrocyte Enucleation
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