MRAP2 and ISLR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MRAP2	ISLR2
Description		melanocortin 2 receptor accessory protein 2	immunoglobulin superfamily containing leucine rich repeat 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Signaling Receptor Regulator Activity Corticotropin Hormone Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 5 Melanocortin Receptor Binding Identical Protein Binding Type 1 Melanocortin Receptor Binding	Protein Binding
	Biological Process	Energy Reserve Metabolic Process Feeding Behavior Protein Localization To Plasma Membrane Energy Homeostasis Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane	Nervous System Development Positive Regulation Of Axon Extension
Pathways
Drugs
Diseases
GWAS		Schizophrenia ( 28991256) Whole brain grey matter density ( 31530798)	Blood protein levels ( 30072576)
Interacting Genes		6 interacting genes: APH1A APP ISLR2 MC2R SGTA TMEM80	6 interacting genes: EMP1 LAPTM4B MRAP2 NKG7 STRIT1 UPK1B
Entrez ID		112609	57611
HPRD ID		12843	13865
Ensembl ID		ENSG00000135324	ENSG00000167178
Uniprot IDs		Q96G30	Q6UXK2
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Corticotropin Receptor Activity TRC Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Melanocortin Receptor Activity BAT3 Complex Binding Positive Regulation Of Proteolysis Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Protein Catabolic Process Axon Choice Point Recognition Negative Regulation Of ERAD Pathway Gamma-secretase Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion	Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cytolytic Granule Membrane Apical Plasma Membrane Urothelial Plaque Regulation Of Lysosomal Membrane Permeability Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 5 Melanocortin Receptor Binding Corticotropin Hormone Receptor Binding Type 1 Melanocortin Receptor Binding Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Lysosomal Protein Catabolic Process Multivesicular Body, Internal Vesicle Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Natural Killer Cell Degranulation Immune Response To Tumor Cell Signaling Receptor Regulator Activity Ceramide Binding Bleb Assembly Membrane Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Phosphatidylinositol Bisphosphate Binding Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Lysosome Organization Lysosomal Membrane Organization Regulation Of Skeletal Muscle Contraction Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
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