MRAP2 and TMEM80

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MRAP2	TMEM80
Description		melanocortin 2 receptor accessory protein 2	transmembrane protein 80
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Cilium Membrane Ciliary Transition Zone Cell Projection
	Molecular Function	Protein Binding Signaling Receptor Regulator Activity Corticotropin Hormone Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 5 Melanocortin Receptor Binding Identical Protein Binding Type 1 Melanocortin Receptor Binding	Protein Binding
	Biological Process	Energy Reserve Metabolic Process Feeding Behavior Protein Localization To Plasma Membrane Energy Homeostasis Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane	Non-motile Cilium Assembly
Pathways
Drugs
Diseases
GWAS		Schizophrenia ( 28991256) Whole brain grey matter density ( 31530798)
Interacting Genes		6 interacting genes: APH1A APP ISLR2 MC2R SGTA TMEM80	65 interacting genes: ADGRE2 AGTR1 AIG1 AQP1 ARL6IP6 BET1 BIK C11orf24 C14orf180 C3orf52 C5orf46 CCDC167 CD63 CLDN11 CLDN19 CLDN8 CLDND2 CLEC2D CMTM5 CNIH3 COL4A5 CXCR2 CYBC1 DOLK EMD ERMP1 FAM20B FAM3C FKBP8 FXYD3 GPR37L1 IER3IP1 LAT LSMEM1 MALL MRAP2 NKG7 PRB1 PTPN9 PTPRN RPRM SERP2 SLC30A8 SLC66A2 SMAGP SMCO4 STATH STX7 SYNGR1 TLCD1 TMEM100 TMEM107 TMEM109 TMEM120B TMEM128 TMEM14A TMEM243 TMEM65 TNFRSF10C TRARG1 TSPAN1 TSPO2 TVP23B VKORC1L1 WNT4
Entrez ID		112609	283232
HPRD ID		12843	14143
Ensembl ID		ENSG00000135324	ENSG00000177042
Uniprot IDs		Q96G30	A0A0A0MTU4 A0AAA9X375 E9PQJ9 Q96HE8
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Corticotropin Receptor Activity TRC Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Melanocortin Receptor Activity BAT3 Complex Binding Positive Regulation Of Proteolysis Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Protein Catabolic Process Axon Choice Point Recognition Negative Regulation Of ERAD Pathway Gamma-secretase Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion	Membrane Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Protein Binding
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