HRH3 and DRD1

Number of citations of the paper that reports this interaction (PMID 19413572)
20

Data Source:
BioGRID (fluorescent resonance energy transfer)

		HRH3	DRD1
Gene Name		histamine receptor H3	dopamine receptor D1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Myelin Sheath	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Histamine Receptor Activity Drug Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neurotransmitter Secretion Brain Development Learning Memory Negative Regulation Of Glutamate Secretion Negative Regulation Of Gamma-aminobutyric Acid Secretion Regulation Of Norepinephrine Secretion Negative Regulation Of Serotonin Secretion Response To Organic Cyclic Compound Eating Behavior Drinking Behavior Negative Regulation Of Blood Pressure Positive Regulation Of Epithelial Cell Proliferation	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synapse Assembly Memory Mating Behavior Grooming Behavior Adult Walking Behavior Visual Learning Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Astrocyte Development Dopamine Transport Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Positive Regulation Of CAMP Biosynthetic Process Operant Conditioning Regulation Of Dopamine Metabolic Process Vasodilation Dopamine Metabolic Process Response To Drug Maternal Behavior Positive Regulation Of Potassium Ion Transport Glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long Term Synaptic Depression Cellular Response To Catecholamine Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Histamine receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs		Histamine Phosphate Betahistine	Ziprasidone Cabergoline Ropinirole Olanzapine Methylergonovine Clozapine Thiethylperazine Phenylpropanolamine Loxapine Pramipexole Promazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lisuride Fluphenazine Thioridazine Apomorphine Trimipramine Risperidone Propiomazine Fenoldopam Minaprine Perphenazine Flupenthixol Dopamine Carphenazine Acetophenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Dihydroergotoxine Methotrimeprazine Propericiazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Asenapine
Diseases
GWAS		Prostate cancer ( 23535732)	Obesity-related traits ( 23251661) Treatment response for severe sepsis ( 22310353)
Protein-Protein Interactions		1 interactors: DRD1	11 interactors: ADA ADORA1 CALY CAV2 COPG1 COPG2 DNAJC14 EPB41L2 FLNA GRIN1 HRH3
Entrez ID		11255	1812
HPRD ID		05162	00538
Ensembl ID		ENSG00000101180	ENSG00000184845
Uniprot IDs		Q9Y5N1	P21728
PDB IDs			1OZ5
Enriched GO Terms of Interacting Partners?		Sensitization Habituation Nonassociative Learning Conditioned Taste Aversion Operant Conditioning Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Cerebral Cortex GABAergic Interneuron Migration Glucose Import Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Interneuron Migration From The Subpallium To The Cortex Dopamine Transport Cerebral Cortex GABAergic Interneuron Differentiation Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Peristalsis Regulation Of Neurotransmitter Uptake Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway GABAergic Neuron Differentiation Striatum Development Prepulse Inhibition Maternal Behavior Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Long Term Synaptic Depression Dentate Gyrus Development Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Dopamine Metabolic Process Grooming Behavior Astrocyte Development Positive Regulation Of Synaptic Transmission, Glutamatergic Subpallium Development Temperature Homeostasis Monoamine Transport Cellular Response To Catecholamine Stimulus Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Startle Response Dopamine Metabolic Process Positive Regulation Of Potassium Ion Transport Activation Of Adenylate Cyclase Activity Neuronal Action Potential Mating Behavior Vasodilation Cerebral Cortex Neuron Differentiation Response To Amphetamine Dopamine Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Behavioral Fear Response Forebrain Neuron Development Positive Regulation Of Calcium Ion Transport Into Cytosol	Negative Regulation Of Mucus Secretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Transport Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Glutamate Secretion Vesicle-mediated Transport Negative Regulation Of Transport Membrane Organization Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Mucus Secretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Circadian Rhythm Negative Regulation Of Leukocyte Migration Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Secretion Vesicle Organization Dopamine Receptor Signaling Pathway Retrograde Vesicle-mediated Transport, Golgi To ER Response To Morphine Negative Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Cognition Establishment Of Protein Localization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Long Term Synaptic Depression Negative Regulation Of Neurotrophin Production Deoxyadenosine Catabolic Process Positive Regulation Of Nucleoside Transport Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Propylene Metabolic Process Xanthine Biosynthetic Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Membrane Budding Sensory Perception Of Pain Response To Ammonium Ion Protein Complex Assembly Negative Regulation Of Ion Transport Regulation Of Circadian Rhythm Feeding Behavior Olfactory Learning Negative Regulation Of Gamma-aminobutyric Acid Secretion Purine Deoxyribonucleoside Metabolic Process Protein Localization Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell
Tagcloud ?			adrenocorticotropic appetite blair denton embodied experimentation fitzsimons gluco gratification gratified instinct instinctive instincts intricately johnson lehrman liedtke luca mineralocorticoids respected richter roitman satiation sentiment suprarenal thirst thunhorst veteran wolf
Tagcloud (Difference) ?			adrenocorticotropic appetite blair denton embodied experimentation fitzsimons gluco gratification gratified instinct instinctive instincts intricately johnson lehrman liedtke luca mineralocorticoids respected richter roitman satiation sentiment suprarenal thirst thunhorst veteran wolf
Tagcloud (Intersection) ?