HRH3

Gene Name		histamine receptor H3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Myelin Sheath
	Molecular Function	Histamine Receptor Activity Drug Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neurotransmitter Secretion Brain Development Learning Memory Negative Regulation Of Glutamate Secretion Negative Regulation Of Gamma-aminobutyric Acid Secretion Regulation Of Norepinephrine Secretion Negative Regulation Of Serotonin Secretion Response To Organic Cyclic Compound Eating Behavior Drinking Behavior Negative Regulation Of Blood Pressure Positive Regulation Of Epithelial Cell Proliferation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Histamine receptors
Drugs		Histamine Phosphate Betahistine
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-protein Interactions		1 interactors: DRD1
Entrez ID		11255
HPRD ID		05162
Ensembl ID		ENSG00000101180
Uniprot IDs		Q9Y5N1
PDB IDs
Enriched GO Terms of Interacting Partners?		Sensitization Habituation Nonassociative Learning Conditioned Taste Aversion Operant Conditioning Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Cerebral Cortex GABAergic Interneuron Migration Glucose Import Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Interneuron Migration From The Subpallium To The Cortex Dopamine Transport Cerebral Cortex GABAergic Interneuron Differentiation Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Peristalsis Regulation Of Neurotransmitter Uptake Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway GABAergic Neuron Differentiation Striatum Development Prepulse Inhibition Maternal Behavior Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Long Term Synaptic Depression Dentate Gyrus Development Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Dopamine Metabolic Process Grooming Behavior Astrocyte Development Positive Regulation Of Synaptic Transmission, Glutamatergic Subpallium Development Temperature Homeostasis Monoamine Transport Cellular Response To Catecholamine Stimulus Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Startle Response Dopamine Metabolic Process Positive Regulation Of Potassium Ion Transport Activation Of Adenylate Cyclase Activity Neuronal Action Potential Mating Behavior Vasodilation Cerebral Cortex Neuron Differentiation Response To Amphetamine Dopamine Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Behavioral Fear Response Forebrain Neuron Development Positive Regulation Of Calcium Ion Transport Into Cytosol
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