RNF24 and NT5E

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		RNF24	NT5E
Name		ring finger protein 24	5'-nucleotidase ecto
Structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding 5'-deoxynucleotidase Activity Protein Binding 5'-nucleotidase Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Identical Protein Binding Metal Ion Binding
	Biological Process	None	AMP Catabolic Process DNA Metabolic Process Leukocyte Cell-cell Adhesion Nucleotide Catabolic Process Response To ATP ADP Catabolic Process ATP Metabolic Process Adenosine Biosynthetic Process Negative Regulation Of Inflammatory Response Calcium Ion Homeostasis Inhibition Of Non-skeletal Tissue Mineralization
Pathways		None	Nicotinate metabolism Pyrimidine catabolism Purine catabolism Purinergic signaling in leishmaniasis infection
Drugs		None	Pentoxifylline
Diseases		None	Calcification of joints and arteries
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Height ( 31562340 ) Nevirapine-induced hypersensitivity in HIV (drug-induced liver injury) ( 28062682 ) PR interval ( 32439900 ) Response to antidepressants in depression ( 27622933 ) Triglyceride levels in HIV infection ( 33109212 )	Hippocampal volume in Alzheimer's disease dementia ( 29274321 ) Lung function ( 31902109 ) Metabolic traits ( 21886157 ) Serum metabolite levels ( 33031748 )
Novel Interactors		None recorded	1 novel interactors: ATP6AP1
Interacting Genes		17 interacting genes: ABHD5 ARMC1 BNIP3 CNIH1 GOLT1A LHFPL3 NKG7 NRSN1 NT5E PLP1 SLC10A6 SLC71A2 TIMMDC1 TMX2 TRPC6 UQCRH VAMP1	6 interacting genes: ACTB AFF1 FN1 LAMA1 RNF24 ZNRF4
Entrez ID		11237	4907
HPRD ID		10198	00552
Ensembl ID		ENSG00000101236	ENSG00000135318
Uniprot IDs		Q9Y225	P21589 Q6NZX3
PDB IDs		2EP4	4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I 6HXW 6S7F 6S7H 6TVE 6TVG 6TVX 6TW0 6TWA 6TWF 6VC9 6VCA 6XUE 6XUG 6XUQ 6YE1 6YE2 6Z9B 6Z9D 7BBJ 7JV8 7JV9 7P9N 7P9R 7P9T 7PA4 7PB5 7PBA 7PBB 7PBY 7PCP 7PD9 7QGA 7QGL 7QGM 7QGO 8ZNZ
GO Terms Enriched among Interactors		Membrane Granzyme-mediated Programmed Cell Death Signaling Pathway	Positive Regulation Of Cell Adhesion Regulation Of Transepithelial Transport Blood Microparticle Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Transporter Regulator Activity Cellular Response To Cytochalasin B Negative Regulation Of Monocyte Activation Calcium-independent Cell-matrix Adhesion Basement Membrane Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Extracellular Matrix Structural Constituent Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Laminin-1 Complex Laminin-3 Complex Laminin Complex BBAF Complex Tat Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Cell Adhesion Nitric-oxide Synthase Regulator Activity Cell-cell Junction Postsynaptic Actin Cytoskeleton Cell Adhesion Protein Localization To Adherens Junction Positive Regulation Of Cell Differentiation Dense Body Morphogenesis Of A Polarized Epithelium Establishment Or Maintenance Of Cell Polarity Osteoclast Development Proton-transporting Two-sector ATPase Complex Golgi Lumen Acidification Peptidase Activator Activity Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex Neural Crest Cell Migration Involved In Autonomic Nervous System Development Super Elongation Complex Retina Vasculature Morphogenesis In Camera-type Eye Retinal Blood Vessel Morphogenesis Regulation Of Basement Membrane Organization Glycosphingolipid Binding Protein Complex Involved In Cell-matrix Adhesion Nitric-oxide Synthase Binding Cell Junction Assembly Transporter Activator Activity Endomembrane System Integrin Activation Negative Regulation Of Transforming Growth Factor Beta Production Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Branching Involved In Salivary Gland Morphogenesis