BAZ1A and SMARCA5

Number of citations of the paper that reports this interaction (PubMedID 11980720)
53

Data Source:
HPRD (in vitro, in vivo)

		BAZ1A	SMARCA5
Description		bromodomain adjacent to zinc finger domain 1A	SNF2 related chromatin remodeling ATPase 5
Image
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Pericentric Heterochromatin CHRAC ACF Complex	Chromatin Condensed Chromosome Fibrillar Center Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Pericentric Heterochromatin Nucleolus CHRAC NURF Complex ACF Complex ISWI-type Complex RSF Complex Site Of Double-strand Break Nuclear Replication Fork WICH Complex NoRC Complex CERF Complex B-WICH Complex
	Molecular Function	DNA Binding Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nucleosome Binding Histone Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity Histone Octamer Slider Activity
	Biological Process	DNA-templated DNA Replication Regulation Of DNA Replication Nucleosome Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Heterochromatin Formation Positive Regulation Of DNA Replication	RDNA Heterochromatin Formation Regulation Of DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Transcription By RNA Polymerase I Heterochromatin Formation Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Antiviral Innate Immune Response Negative Regulation Of Mitotic Chromosome Condensation Cellular Response To Leukemia Inhibitory Factor
Pathways			NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Deposition of new CENPA-containing nucleosomes at the centromere
Drugs			Beta-D-Glucose 4-Deoxy-Alpha-D-Glucose
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immature fraction of reticulocytes ( 32888494 27863252) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Non-small cell lung cancer ( 31326317) Red blood cell count ( 32888494) Response to bupropion in depression ( 27622933) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Appendicular lean mass ( 33097823) Height ( 31562340) Malaria ( 31844061)
Interacting Genes		9 interacting genes: MTNR1A SATB1 SMAD2 SMAD9 SMARCA5 SRPK2 SUMO2 XRCC5 XRCC6	20 interacting genes: BAZ1A BAZ1B BAZ2A CDT1 CHRAC1 CREB1 CTNNB1 DNMT3B GSK3A H3-3A H3C1 H4C16 HDAC2 MAF POLE3 PTEN RAD21 RSF1 SATB1 USP7
Entrez ID		11177	8467
HPRD ID		12034	04538
Ensembl ID		ENSG00000198604	ENSG00000153147
Uniprot IDs		Q9NRL2	O60264
PDB IDs		5UIY	6NE3 8V4Y 8V6V 8V7L 9E1L 9E1M 9E1N 9E1O 9E1P 9E1Q 9E1R 9E1U 9E1V 9E1W 9E1X
Enriched GO Terms of Interacting Partners?		Double-stranded DNA Binding DNA End Binding Ku70:Ku80 Complex DNA-dependent Protein Kinase Complex DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity SMAD Protein Complex Nonhomologous End Joining Complex Heteromeric SMAD Protein Complex Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Regulation Of RNA Metabolic Process I-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Helicase Activity Nucleoplasm SMAD Protein Signal Transduction Telomeric DNA Binding Cellular Response To Gamma Radiation Chromatin ATP-dependent Activity, Acting On DNA Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Helicase Activity Transcription Regulator Complex Innate Immune Response Negative Regulation Of DNA-templated Transcription Protein-DNA Complex DNA Binding Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Chromosome Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Response To Gamma Radiation Negative Regulation Of RNA Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin Protein Ligase Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Damaged DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Ionizing Radiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process	Chromatin Remodeling Chromatin Organization Protein-DNA Complex Assembly Nucleosome Assembly Nucleosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process CHRAC Negative Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Pericentric Heterochromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Chromatin Negative Regulation Of Gene Expression, Epigenetic Macromolecule Metabolic Process Cellular Component Assembly Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Fungiform Papilla Formation Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Chromosome Organization Negative Regulation Of Chromosome Condensation Regulation Of DNA Replication Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Hair Follicle Placode Formation Epsilon DNA Polymerase Complex Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression DNA Replication DNA-templated DNA Replication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process
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