ADAMTS5 and MMP13

Number of citations of the paper that reports this interaction (PMID 11032846)
12

Data Source:
HPRD (in vitro)

		ADAMTS5	MMP13
Gene Name		ADAM metallopeptidase with thrombospondin type 1 motif, 5	matrix metallopeptidase 13 (collagenase 3)
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Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Endoplasmic Reticulum Lumen	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding	Metalloendopeptidase Activity Calcium Ion Binding Collagen Binding Zinc Ion Binding
	Biological Process	Protein O-linked Glycosylation Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Protein O-linked Fucosylation Defense Response To Bacterium Post-translational Protein Modification Cellular Protein Metabolic Process	Endochondral Ossification Growth Plate Cartilage Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Bone Mineralization Collagen Catabolic Process Cellular Protein Metabolic Process Bone Morphogenesis
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins Degradation of the extracellular matrix O-linked glycosylation	Collagen formation Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs			Marimastat 3-Methylpyridine 2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide WAY-151693 Hydroxyaminovaline 1-Methyloxy-4-Sulfone-Benzene PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE] TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID 5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE 4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE
Diseases
GWAS		Dialysis-related mortality ( 21546767)
Protein-Protein Interactions		2 interactors: ACAN MMP13	8 interactors: ADAMTS5 BCAN CCL7 COL2A1 F12 LRP1 MMP14 TIMP3
Entrez ID		11096	4322
HPRD ID		05420	02522
Ensembl ID		ENSG00000154736	ENSG00000137745
Uniprot IDs		Q9UNA0	A8K846 G5E971 P45452 Q53H33
PDB IDs		2RJQ 3B8Z 3HY7 3HY9 3HYG 3LJT	1EUB 1FLS 1FM1 1PEX 1UC1 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 2YIG 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 3O2X 3TVC 3ZXH 456C 4A7B 4FU4 4FVL 4G0D 830C
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Cartilage Development Connective Tissue Development Skeletal System Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Skeletal System Development Keratan Sulfate Catabolic Process Growth Plate Cartilage Development Organ Morphogenesis Keratan Sulfate Biosynthetic Process Cartilage Condensation Keratan Sulfate Metabolic Process Endochondral Bone Growth Chondrocyte Development Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Bone Mineralization Proteolysis Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Collagen Fibril Organization Collagen Catabolic Process Tissue Development Catabolic Process Biomineral Tissue Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endochondral Bone Morphogenesis Chondrocyte Differentiation Multicellular Organismal Metabolic Process Glycosaminoglycan Biosynthetic Process Organ Growth Proteoglycan Metabolic Process Bone Morphogenesis Anatomical Structure Morphogenesis Developmental Growth Involved In Morphogenesis Glycosaminoglycan Metabolic Process Organ Development Pathogenesis Bone Development Developmental Growth Ossification Sulfur Compound Metabolic Process System Development	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endochondral Ossification Response To External Stimulus Collagen Catabolic Process Collagen Metabolic Process Endochondral Bone Morphogenesis Glycoprotein Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Beta-amyloid Clearance Multicellular Organismal Metabolic Process Proteoglycan Metabolic Process Zymogen Activation Response To Organic Substance Factor XII Activation Skeletal System Development Bone Morphogenesis Embryonic Skeletal System Morphogenesis Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Fibrinolysis Embryonic Skeletal System Development Visual Perception Sensory Perception Of Light Stimulus Positive Regulation Of Plasminogen Activation Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Cardiovascular System Development Astrocyte Cell Migration Bone Development Protein Processing Eosinophil Chemotaxis Protein Metabolic Process Eosinophil Migration Chondrocyte Proliferation Cellular Response To Ethanol Response To Stimulus Protein Autoprocessing Limb Bud Formation Plasma Kallikrein-kinin Cascade Skeletal System Morphogenesis Protein O-linked Fucosylation Dermatan Sulfate Biosynthetic Process Ossification Regulation Of Phospholipase A2 Activity
Tagcloud ?		1ss aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled	advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eif3i eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis ogx option proliferative promoted shorter silencing suppressing turn utilized
Tagcloud (Difference) ?		1ss aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled	advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eif3i eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis ogx option proliferative promoted shorter silencing suppressing turn utilized
Tagcloud (Intersection) ?