ADAMTS5

Description		ADAM metallopeptidase with thrombospondin type 1 motif 5
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Heparin Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding Extracellular Matrix Binding
	Biological Process	Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis Proteolysis Myoblast Fusion Extracellular Matrix Disassembly Extracellular Matrix Organization Defense Response To Bacterium Negative Regulation Of Cold-induced Thermogenesis
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs		Batimastat (2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide
Diseases
GWAS		Blood protein levels ( 30072576) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 29343252) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		2 interacting genes: ACAN MMP13
Entrez ID		11096
HPRD ID		05420
Ensembl ID		ENSG00000154736
Uniprot IDs		Q9UNA0
PDB IDs		2RJQ 3B8Z 3HY7 3HY9 3HYG 3LJT 6YJM
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Perineuronal Net Growth Plate Cartilage Development Hyaluronic Acid Binding Proteolysis Endochondral Ossification Collagen Catabolic Process Cartilage Development Involved In Endochondral Bone Morphogenesis Bone Morphogenesis Extracellular Space Bone Mineralization Collagen Metabolic Process Collagen Binding Connective Tissue Development Response To Amyloid-beta Extracellular Matrix Disassembly Lysosomal Lumen Biomineral Tissue Development Metalloendopeptidase Activity Endopeptidase Activity Golgi Lumen Cartilage Development Extracellular Matrix Structural Constituent Extracellular Region Ossification Metallopeptidase Activity Central Nervous System Development Serine-type Endopeptidase Activity Carbohydrate Binding Skeletal System Development
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