ADAMTS5

Gene Name		ADAM metallopeptidase with thrombospondin type 1 motif, 5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Endoplasmic Reticulum Lumen
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Protein O-linked Glycosylation Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Protein O-linked Fucosylation Defense Response To Bacterium Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins Degradation of the extracellular matrix O-linked glycosylation
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767)
Protein-protein Interactions		2 interactors: ACAN MMP13
Entrez ID		11096
HPRD ID		05420
Ensembl ID		ENSG00000154736
Uniprot IDs		Q9UNA0
PDB IDs		2RJQ 3B8Z 3HY7 3HY9 3HYG 3LJT
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Cartilage Development Connective Tissue Development Skeletal System Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Skeletal System Development Keratan Sulfate Catabolic Process Growth Plate Cartilage Development Organ Morphogenesis Keratan Sulfate Biosynthetic Process Cartilage Condensation Keratan Sulfate Metabolic Process Endochondral Bone Growth Chondrocyte Development Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Bone Mineralization Proteolysis Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Collagen Fibril Organization Collagen Catabolic Process Tissue Development Catabolic Process Biomineral Tissue Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endochondral Bone Morphogenesis Chondrocyte Differentiation Multicellular Organismal Metabolic Process Glycosaminoglycan Biosynthetic Process Organ Growth Proteoglycan Metabolic Process Bone Morphogenesis Anatomical Structure Morphogenesis Developmental Growth Involved In Morphogenesis Glycosaminoglycan Metabolic Process Organ Development Pathogenesis Bone Development Developmental Growth Ossification Sulfur Compound Metabolic Process System Development
Tagcloud ?		1ss aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled