HELQ

Description		helicase, POLQ like
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Site Of DNA Damage
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Single-stranded 3'-5' DNA Helicase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Double-strand Break Repair Via Synthesis-dependent Strand Annealing Double-strand Break Repair Via Alternative Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Drugs
Diseases
GWAS		Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325) Breast cancer ( 29059683) Menopause (age at onset) ( 22267201 26414677 29773799)
Interacting Genes		1 interacting genes: RIPK3
Entrez ID		113510
HPRD ID		08422
Ensembl ID		ENSG00000163312
Uniprot IDs		E3W980 Q8TDG4
PDB IDs
Enriched GO Terms of Interacting Partners?		Execution Phase Of Necroptosis Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Regulation Of Activation-induced Cell Death Of T Cells Positive Regulation Of Necroptotic Process Necroptotic Signaling Pathway Positive Regulation Of Programmed Necrotic Cell Death Necroptotic Process Lymph Node Development Programmed Necrotic Cell Death Spleen Development Regulation Of Activated T Cell Proliferation T Cell Homeostasis Regulation Of T Cell Mediated Cytotoxicity Activation Of Protein Kinase Activity Regulation Of Necroptotic Process Regulation Of Cellular Extravasation Amyloid Fibril Formation T Cell Differentiation In Thymus Non-canonical NF-kappaB Signal Transduction Regulation Of Programmed Necrotic Cell Death Regulation Of T Cell Apoptotic Process Regulation Of T Cell Migration Thymus Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Lymphocyte Migration Lymphocyte Homeostasis Regulation Of Lymphocyte Apoptotic Process Cellular Response To Hydrogen Peroxide Positive Regulation Of NF-kappaB Transcription Factor Activity Leukocyte Homeostasis Hematopoietic Or Lymphoid Organ Development Reactive Oxygen Species Metabolic Process Regulation Of Leukocyte Mediated Cytotoxicity Response To Hydrogen Peroxide Regulation Of T Cell Mediated Immunity Cellular Response To Reactive Oxygen Species Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Type II Interferon Production Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mononuclear Cell Migration T Cell Differentiation Response To Reactive Oxygen Species Regulation Of DNA-binding Transcription Factor Activity Regulation Of T Cell Proliferation Regulation Of Intrinsic Apoptotic Signaling Pathway Homeostasis Of Number Of Cells
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