TLK2 and DCAF7

		TLK2	DCAF7
Description		tousled like kinase 2	DDB1 and CUL4 associated factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Intermediate Filament Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Nuclear Body Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Chromatin Organization Protein Phosphorylation DNA Damage Response Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Nucleus Localization Cellular Response To Gamma Radiation Regulation Of Chromatin Organization	Protein Ubiquitination
Pathways			Association of TriC/CCT with target proteins during biosynthesis Neddylation
Drugs		Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lifespan ( 25918517) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		17 interacting genes: ASF1A ASF1B AURKA CEP70 DMAP1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ	7 interacting genes: APP ATP13A2 BMPR1B DYRK1B LIG1 PWP2 YWHAG
Entrez ID		11011	10238
HPRD ID		10527	09340
Ensembl ID		ENSG00000146872	ENSG00000136485
Uniprot IDs		A0A804HJZ9 A0A804HK10 B4DUC2 J3QLK5 Q86UE8	P61962
PDB IDs		5O0Y 7LO0
Enriched GO Terms of Interacting Partners?		Chromatin Organization DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Regulation Of Vacuole Organization Negative Regulation Of Autophagosome Assembly Histone Chaperone Activity Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Toll-like Receptor Signaling Pathway Chromatin Positive Regulation Of Metalloendopeptidase Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Coregulator Binding SUMO Conjugating Enzyme Activity Negative Regulation Of Macroautophagy Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Gamma-tubulin Binding Nucleus Regulation Of Autophagosome Assembly	Cellular Response To Manganese Ion Response To Manganese Ion Cellular Response To Stress
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