PNRC1 and RORA

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PNRC1	RORA
Gene Name		proline-rich nuclear receptor coactivator 1	RAR-related orphan receptor A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm
	Molecular Function	Protein Binding	Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Direct Ligand Regulated Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Angiogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Circadian Rhythm Regulation Of Smoothened Signaling Pathway Gene Expression Positive Regulation Vascular Endothelial Growth Factor Production Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Precursor Proliferation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Muscle Cell Differentiation Positive Regulation Of Circadian Rhythm Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter CGMP Metabolic Process Negative Regulation Of Inflammatory Response Regulation Of Transcription Involved In Cell Fate Commitment Triglyceride Homeostasis Cellular Response To Hypoxia T-helper 17 Cell Differentiation Regulation Of Cholesterol Homeostasis
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Nuclear Receptor transcription pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS			Asthma ( 20860503) Breast cancer (prognosis) ( 23319801) C-reactive protein ( 21300955) Depression (quantitative trait) ( 20800221) Gamma gluatamyl transferase levels ( 22010049) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Menarche (age at onset) ( 21102462 23599027) Pulmonary function decline ( 22424883) Response to citalopram treatment ( 19846067) Schizophrenia ( 23212062) Subcutaneous adipose tissue ( 22589738) Total ventricular volume ( 21116278)
Protein-Protein Interactions		12 interactors: AR ESR2 ESRRG GRB2 HNF4A HNF4G MAPK8 NR5A2 RARB RARG RORA RORB	20 interactors: COPS5 EIF3I EP300 GFAP LMO3 LRIF1 MED1 MYOD1 NCOA1 NCOA2 NME1 NME2 NR0B1 NSD1 PNRC1 PNRC2 PROX1 PSMC5 SMARCD3 ZXDC
Entrez ID		10957	6095
HPRD ID		08412	02896
Ensembl ID		ENSG00000146278	ENSG00000069667
Uniprot IDs		Q12796	F1DAL0 P35398
PDB IDs			1N83 1S0X
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Lipid Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Response To Steroid Hormone Response To Lipid Response To Hormone Cellular Response To Organic Substance Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Organic Substance Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Signal Transduction Signaling Cell Communication Organ Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Response To Stimulus Retinoic Acid Receptor Signaling Pathway Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process System Development Endocrine Pancreas Development Response To Stimulus Nucleobase-containing Compound Metabolic Process Retinal Pigment Epithelium Development Multicellular Organismal Development Prostate Gland Development	Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Cellular Metabolic Process Limbic System Development Peptidyl-lysine Modification Response To Steroid Hormone Regulation Of Cell Differentiation Histone Acetylation Positive Regulation Of Cell Development Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Positive Regulation Of Metabolic Process Internal Protein Amino Acid Acetylation Regulation Of Cell Development Protein Acetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Chromatin Modification Response To Hormone Positive Regulation Of Epithelial Cell Proliferation Histone H4 Acetylation Histone Modification Regulation Of Neurogenesis
Tagcloud ?			15q21 backcross cdna chromosomal chromosome clone fluorescence hybridization interspecific map mapped member mouse partial places pml promyelocytic proximity q22 rara reciprocal retinoid situ steroid superfamily thyroid translocation unique
Tagcloud (Difference) ?			15q21 backcross cdna chromosomal chromosome clone fluorescence hybridization interspecific map mapped member mouse partial places pml promyelocytic proximity q22 rara reciprocal retinoid situ steroid superfamily thyroid translocation unique
Tagcloud (Intersection) ?