CFHR4 and C3

Number of citations of the paper that reports this interaction (PMID 10622723)
15

Data Source:
HPRD (in vitro, in vivo)

		CFHR4	C3
Gene Name		complement factor H-related 4	complement component 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Lipid Transporter Activity	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding
	Biological Process	Lipid Transport	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Glucose Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Angiogenesis Regulation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Alternative complement activation Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Metabolic disorders of biological oxidation enzymes GPCR ligand binding Initial triggering of complement GPCR downstream signaling Peptide ligand-binding receptors Regulation of Complement cascade Complement cascade G alpha (i) signalling events Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23577725 23536807) Age-related macular degeneration (extreme sampling) ( 23577725) End-stage coagulation ( 23381943) Nephropathy ( 21399633)	Age-related macular degeneration ( 20385819 20385826 23455636 20861866 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (GA) ( 22705344) Complement C3 and C4 levels ( 23028341)
Protein-Protein Interactions		2 interactors: C3 CDC42	27 interactors: ABL1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG GC ITGAM ITGAX LAMA1 LRP1 MASP1 OLFM4 PAPPA TGM2 VSIG4
Entrez ID		10877	718
HPRD ID		05627	00400
Ensembl ID		ENSG00000134365	ENSG00000125730
Uniprot IDs		Q5DVJ7 Q92496	P01024
PDB IDs			1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2HR0 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Type IIa Hypersensitivity Regulation Of Lipid Metabolic Process Actin Filament Branching Submandibular Salivary Gland Formation Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Activation Of Membrane Attack Complex Establishment Of Golgi Localization Positive Regulation Of Metalloenzyme Activity Positive Regulation Of Hypersensitivity Positive Regulation Of Apoptotic Cell Clearance Neuron Fate Determination Epithelial-mesenchymal Cell Signaling Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Protein Heterodimerization Activity Positive Regulation Of Immune Response Keratinocyte Development Regulation Of Synapse Structural Plasticity Regulation Of Apoptotic Cell Clearance Positive Regulation Of Protein Phosphorylation Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Transport Positive Regulation Of Pseudopodium Assembly Nuclear Migration Cardiac Conduction System Development Golgi Localization Innate Immune Response Positive Regulation Of Humoral Immune Response Positive Regulation Of Phosphorylation Regulation Of Immune Response Filopodium Assembly Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Hair Follicle Placode Formation Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process Macrophage Differentiation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Dendritic Cell Migration Regulation Of Protein Phosphorylation Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Nucleus Localization Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Complement Activation	Complement Activation Regulation Of Complement Activation Protein Activation Cascade Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Humoral Immune Response Humoral Immune Response Regulation Of Immune System Process Defense Response Regulation Of Acute Inflammatory Response Positive Regulation Of Immune System Process Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Innate Immune Response Immune Response Immune System Process Response To Stress Regulation Of Protein Processing Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Receptor Mediated Signaling Pathway Leukocyte Mediated Immunity Response To Stimulus Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Protein Metabolic Process Negative Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Adaptive Immune Response Negative Regulation Of Complement Activation Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Cytokine Production Negative Regulation Of Immune Response Negative Regulation Of Leukocyte Chemotaxis Chemotaxis Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Macrophage Chemotaxis Immune Response-regulating Signaling Pathway Proteolysis Leukocyte Migration Involved In Inflammatory Response Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Migration Cellular Calcium Ion Homeostasis Lymphocyte Proliferation Locomotion
Tagcloud ?			accordance antioxidants asp assignment boc buckminsterfullerene c60 carboxyfullerene carboxyfullerenes collapse dopaminergic dugan dyes entirely fluoromethylketone fluorophores hoc hydroxydopamine hydroxylase neurotoxin neurotrophic ohda oxidized phenylpyridinium radicals ros saved temporally toxins
Tagcloud (Difference) ?			accordance antioxidants asp assignment boc buckminsterfullerene c60 carboxyfullerene carboxyfullerenes collapse dopaminergic dugan dyes entirely fluoromethylketone fluorophores hoc hydroxydopamine hydroxylase neurotoxin neurotrophic ohda oxidized phenylpyridinium radicals ros saved temporally toxins
Tagcloud (Intersection) ?