CFHR4

Description		complement factor H related 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Complement Component C3b Binding Lipid Transporter Activity Protein Binding
	Biological Process	Lipid Transport Complement Activation
Pathways		Regulation of Complement cascade
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23536807 23577725) Age-related macular degeneration (extreme sampling) ( 23577725) Complement factor H-related protein 4A levels ( 34260947) End-stage coagulation ( 23381943) Matrix metalloproteinase-8 levels ( 29212897) Nephropathy ( 21399633) Phenytoin-induced maculopapular exanthema ( 29288229) Serum C3d:C3 ratio (systemic complement activation) ( 29398083)
Interacting Genes		2 interacting genes: C3 CDC42
Entrez ID		10877
HPRD ID		05627
Ensembl ID		ENSG00000134365
Uniprot IDs		Q92496
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endocytosis Positive Regulation Of Activation Of Membrane Attack Complex Complement-dependent Cytotoxicity Oviduct Epithelium Development Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Type IIa Hypersensitivity Leukocyte Migration C5L2 Anaphylatoxin Chemotactic Receptor Binding Epithelium Development Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Regulation Of Endocytosis Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Complement Activation, Lectin Pathway Positive Regulation Of Complement Activation Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Regulation Of Apoptotic Cell Clearance Neuron Remodeling Positive Regulation Of Inflammatory Response To Antigenic Stimulus Synapse Pruning Cell Junction Organization Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Phagocytosis, Engulfment Regulation Of Vesicle-mediated Transport Complement Receptor Mediated Signaling Pathway Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Thioesterase Binding Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Golgi Localization Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Tissue Development Complement Activation, Alternative Pathway Opsonization Protein-containing Complex Regulation Of Acute Inflammatory Response To Antigenic Stimulus
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