TUBGCP2 and INPP5A

		TUBGCP2	INPP5A
Description		tubulin gamma complex component 2	inositol polyphosphate-5-phosphatase A
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Gamma-tubulin Complex Nucleoplasm Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Membrane Ciliary Basal Body	Plasma Membrane Membrane Dendrite Cell Projection
	Molecular Function	Protein Binding Gamma-tubulin Binding Microtubule Minus-end Binding	Inositol-polyphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity PH Domain Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Microtubule Nucleation Brain Development Cytoplasmic Microtubule Organization Spindle Assembly Meiotic Cell Cycle Protein-containing Complex Assembly	Phosphate-containing Compound Metabolic Process Organophosphate Metabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Dephosphorylation Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	Synthesis of IP2, IP, and Ins in the cytosol
Drugs
Diseases
GWAS		Mild influenza (H1N1) infection ( 26379185) Nonunion in individuals with fractures ( 30680360)	Femur bone mineral density x serum urate levels interaction ( 34046847) Gait speed in old age ( 28077804) Heel bone mineral density ( 28869591 30598549) Migraine ( 27182965) Primary sclerosing cholangitis ( 27992413) Pulse pressure ( 30578418) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 30275531)
Interacting Genes		4 interacting genes: CEBPA KIF14 PCNT UBC	3 interacting genes: PLEK TEAD2 YWHAZ
Entrez ID		10844	3632
HPRD ID		18245	02521
Ensembl ID		ENSG00000130640	ENSG00000068383
Uniprot IDs		Q53EQ3 Q9BSJ2	Q14642
PDB IDs		6V6B 6V6S 6X0V 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 8Q62 8RX1 8VRD 8VRJ 8VRK 9H9P
Enriched GO Terms of Interacting Partners?			Regulation Of Cell Diameter Protein Secretion By Platelet Negative Regulation Of Inositol Phosphate Biosynthetic Process Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Synaptic Target Recognition Tube Formation Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Platelet Degranulation Golgi Reassembly TEAD-YAP Complex Lateral Mesoderm Development Phosphatase Activator Activity Phosphoserine Residue Binding Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Integrin Activation Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Platelet Activation Regulation Of Lysosome Organization Golgi Localization Establishment Of Golgi Localization Animal Organ Development Notochord Development Paraxial Mesoderm Development Microtubule Minus-end Binding Gamma-tubulin Complex Organelle Localization Positive Regulation Of Protein Depolymerization Intracellular Signal Transduction Regulation Of Integrin Activation Antibacterial Innate Immune Response
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