PPP1R17 and PRKG1

Number of citations of the paper that reports this interaction (PubMedID 10051666)
52

Data Source:
HPRD (in vitro)

		PPP1R17	PRKG1
Description		protein phosphatase 1 regulatory subunit 17	protein kinase cGMP-dependent 1
Image		No pdb structure
GO Annotations	Cellular Component		Acrosomal Vesicle Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Sarcolemma
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Phosphatase Inhibitor Activity	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Kinase Activity Transferase Activity CGMP Binding Identical Protein Binding Mitogen-activated Protein Kinase P38 Binding Protein Serine Kinase Activity
	Biological Process	Central Nervous System Development Regulation Of Phosphatase Activity Intracellular Signal Transduction	Neuron Migration Protein Phosphorylation Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Spermatid Development Heart Development Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Glutamate Secretion Negative Regulation Of Smooth Muscle Cell Migration Dendrite Development CGMP-mediated Signaling Cerebellum Development Actin Cytoskeleton Organization Forebrain Development Vasodilation Positive Regulation Of Circadian Rhythm Regulation Of GTPase Activity Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Contraction Collateral Sprouting Relaxation Of Vascular Associated Smooth Muscle Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Platelet Aggregation Bone Growth Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Testosterone Biosynthetic Process
Pathways			Ca2+ pathway
Drugs
Diseases
GWAS			3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Alcohol misuse (trauma interaction) ( 28265120) Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Appendicular lean mass ( 33097823) Arthritis (juvenile idiopathic) ( 34101054) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Eosinophilic esophagitis ( 34506852) Gait rhythm ( 26219847) HDL cholesterol levels in HIV infection ( 33109212) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol levels in HIV infection ( 33109212) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Stroke ( 32693751) Systolic blood pressure ( 32902719) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		4 interacting genes: APP FBXO7 PRKACA PRKG1	40 interacting genes: ANXA7 AR ARHGEF15 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 MEOX2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RBAK RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRIM54 TRPC3 VASP VHL WDR77 ZNF646
Entrez ID		10842	5592
HPRD ID		06820	08910
Ensembl ID		ENSG00000106341	ENSG00000185532
Uniprot IDs		A0A090N8N7 O96001	B1ALS0 Q13976
PDB IDs			1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T 7LV3 7MBJ 7SSB 7T4T 7T4U 7T4V 7T4W
Enriched GO Terms of Interacting Partners?		Collateral Sprouting Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Small Molecule Metabolic Process Dendrite Development Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Cell Activation Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Calcium-mediated Signaling Regulation Of System Process Regulation Of Steroid Biosynthetic Process Regulation Of Steroid Metabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Acrosomal Vesicle Negative Regulation Of Small Molecule Metabolic Process Developmental Cell Growth Regulation Of Generation Of Precursor Metabolites And Energy Developmental Growth Involved In Morphogenesis Acetylcholine Receptor Activator Activity Regulation Of Calcium Ion Transmembrane Transport Intracellular Signaling Cassette Cell Maturation Lipoprotein Particle Positive Regulation Of Protein Import CGMP-dependent Protein Kinase Activity Negative Regulation Of Inositol Phosphate Biosynthetic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Positive Regulation Of Endocytosis Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Phosphate Metabolic Process PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Calcium-mediated Signaling Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium	Response To Ketone Positive Regulation Of Hormone Secretion Regulation Of Muscle System Process Negative Regulation Of Muscle Contraction Enzyme Binding Regulation Of System Process CGMP-mediated Signaling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Phosphatase Regulator Activity Myosin Phosphatase Regulator Activity Relaxation Of Vascular Associated Smooth Muscle Positive Regulation Of Secretion Cellular Response To Testosterone Stimulus Relaxation Of Smooth Muscle Intracellular Signaling Cassette Epithelial Cell Differentiation Involved In Prostate Gland Development Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Response To Phorbol 13-acetate 12-myristate Response To Alcohol Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anatomical Structure Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Hormone Secretion Response To Purine-containing Compound Epithelial Fluid Transport Regulation Of Smooth Muscle Cell Proliferation Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Protein Homotetramerization Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Negative Regulation Of Sequestering Of Calcium Ion Inositol 1,4,5 Trisphosphate Binding Z Disc Positive Regulation Of Bone Resorption Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Forskolin Sarcoplasmic Reticulum A Band Monoatomic Ion Channel Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Secretion By Cell Regulation Of Cardiac Muscle Hypertrophy Response To Forskolin Regulation Of Muscle Contraction Regulation Of Developmental Process CGMP Metabolic Process Molecular Adaptor Activity
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