USP34

Name	ubiquitin specific peptidase 34
Structure
Novel Interactors	1 novel interactors: WDPCP
Interactors	5 interactors: DYRK1A FTCD MTNR1A MTNR1B UBC
GO Annotations	Cellular Component	Nucleus Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Regulation Of Signal Transduction Wnt Signaling Pathway Protein Deubiquitination Regulation Of Protein Stability Post-translational Protein Modification Protein K48-linked Deubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways	TCF dependent signaling in response to WNT Ub-specific processing proteases
GWAS	Atrial fibrillation ( 30061737 ) Body fat mass ( 28552196 ) Chronotype ( 30696823 ) Crohn's disease ( 22412388 ) Diastolic blood pressure ( 30224653 ) Erectile dysfunction ( 30583798 ) Estimated glomerular filtration rate ( 31152163 ) Height ( 31562340 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Morning person ( 30696823 ) Mosquito bite size ( 28199695 ) Serum alkaline phosphatase levels ( 33547301 ) Serum uric acid levels ( 30993211 29403010 ) Urate levels ( 31578528 )
Entrez ID	9736
HPRD ID	11665
Ensembl ID	ENSG00000115464
Uniprot IDs	Q70CQ2
PDB IDs	7W3R 7W3U
GO Terms Enriched among Interactors ?	Melatonin Receptor Activity Histone H3T45 Kinase Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Camera-type Eye Development Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Axonemal Basal Plate L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide Regulation Of Embryonic Cell Shape Eye Development Circadian Rhythm Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Sensory Organ Development Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep L-histidine Metabolic Process L-histidine Catabolic Process Formate Metabolic Process Septin Cytoskeleton Organization Tongue Morphogenesis Auditory Receptor Cell Morphogenesis Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Podocyte Cell Migration Smooth Endoplasmic Reticulum Membrane Respiratory System Development Rhythmic Process Regulation Of Heterochromatin Formation Digestive System Development RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Folic Acid Binding Neurofilament Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Amide Catabolic Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Tag Activity Hormone Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Plasma Membrane Regulation Of Transmission Of Nerve Impulse