RBBP9 and RBL2

Number of citations of the paper that reports this interaction (PubMedID 9697699)
0

Data Source:
HPRD (in vivo)

		RBBP9	RBL2
Description		RB binding protein 9, serine hydrolase	RB transcriptional corepressor like 2
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GO Annotations	Cellular Component	Nucleoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Hydrolase Activity Serine Hydrolase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Xenobiotic Metabolic Process Response To Nematode Positive Regulation Of Gene Expression Type II Pneumocyte Differentiation	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Body fat mass ( 28552196) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: RB1 RBL1 RBL2 RCBTB2 TERF2IP YRDC	46 interacting genes: BRCA1 BRF1 BRF2 BTG3 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB1 PPP1R9B PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1
Entrez ID		10741	5934
HPRD ID		04217	01576
Ensembl ID		ENSG00000089050	ENSG00000103479
Uniprot IDs		O75884	Q08999
PDB IDs		2QS9 7OEX 9FCR	4XI9 5C1D
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Transcription Regulator Complex Regulation Of Kinase Activity Negative Regulation Of Cell Cycle Process Digestive Tract Development Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Promoter-specific Chromatin Binding Regulation Of Cell Cycle Phase Transition L-threonylcarbamoyladenylate Synthase Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Negative Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of Phosphorylation Negative Regulation Of DNA Recombination At Telomere Chromatin Lock Complex Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Negative Regulation Of Phosphate Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Collagen Fibril Organization Glial Cell Apoptotic Process Rb-E2F Complex TRNA Threonylcarbamoyladenosine Modification Negative Regulation Of Myofibroblast Differentiation Chromatin Organization Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Centromere Complex Assembly Shelterin Complex Tube Development Enucleate Erythrocyte Differentiation Protection From Non-homologous End Joining At Telomere Cyclin/CDK Positive Transcription Elongation Factor Complex Regulation Of Chromosome Organization Regulation Of Myofibroblast Differentiation Regulation Of Collagen Fibril Organization Importin-alpha Family Protein Binding Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Nucleus Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of RNA Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Negative Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Transcription Corepressor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cyclin A2-CDK2 Complex Cell Division Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition Response To Stress Transcription Regulator Complex DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Process Transcription Preinitiation Complex Assembly
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